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Abstract
Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.
There are few studies of structural changes in ascending and descending sensorimotor pathways after stroke, beyond the corticospinal tract, in the brain. Here the authors identify changes in white matter structure in brainstem and spinal cord following stroke, and show its relationship to motor impairment.
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1 Northwestern University, Interdepartmental Neuroscience Program, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507)
2 Polytechnique Montréal, NeuroPoly Lab, Institute of Biomedical Engineering, Montréal, Canada (GRID:grid.183158.6) (ISNI:0000 0004 0435 3292); University of Montreal, Functional Neuroimaging Unit, CRIUGM, Montreal, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2292 3357)
3 Northwestern University, Interdepartmental Neuroscience Program, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507); Northwestern University, Department of Biomedical Engineering, McCormick School of Engineering, Evanston, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507)