Frequency of ABCB1 gene 3435 polymorphism on patients with coronary stent in Surakarta

Abstract

The use of antithrombotic drugs on patients with coronary stent have reduced the risk of stent thrombosis. ABCB1 Gene 3435TT may limit the drugs availability and response. Frequencies of ABCB1 Gene 3435 Polymorphism varied among different populations. This research aimed to identify frequency of 3435 polymorphism on patients with coronary stent in Surakarta. All the patients (who underwent coronary stent, received antithrombotic therapy, and signed for informed consent forms on the period of May 7^th – June 8^th 2018 in doctor Moewardi Hospital) were included in this study. The single nucleotide polymorphism (SNP) was detected by PCR and sequencing. As a result, the frequencies of 3435 TT, 3435 CC, and 3435 TC on 30 patients were 50 % (15 subjects), 33 % (10 patients), and 17 % (5 subjects) respectively. In this study, the mutant T allele carriers was found in majority of the patients.