Abstract

It is known that nanosized liposomes from vegetable and animal phospholipids promote survival and functional adequacy of animal cells in the course of cryopreservation. It is also known that albumine and some polysaccharides have membrane-protective properties. In this paper we investigated whether there is a synergism of cryoprotective action between soybean liposomes and macromolecular compounds: albumine, sodium alginate, methylcellulose, carageenan and hyaluronic acid. To determine the cryoprotective effect we carried out cryopreservation of bull semen using a standard procedure in the presence of the substances under investigation. Albumine and sodium alginate demonstrated the most considerable cryoprotective effect in the presence of liposomes. In addition we determined dimensional characteristics of nanoparticles in a liposome suspension without and with sodium alginate and studied the influence of autoclave treatment on the nanoparticle size and cryoprotective effect of the complex. Autoclaving caused enlargement of a small-sized fraction of nanoparticles, supposedly, sodium alginate aggregates. Besides, the autoclaving did not demonstrate any influence on the cryoprotective efficiency of the mixture.

Details

Title
The use of nanosized liposomes from vegetable phospholipids in combination with albumine and some polysaccharides as cryoprotective agents in the course of cryopreservation
Author
Shishova, N V 1 ; Davydova, G A 2 ; Kombarova, N A 3 ; Davydova, I B 4 ; Poltavtsev, A M 5 ; Zaraisky, E I 5 ; Poltavtseva, R A 6 

 Institute of Cell Biophysics, Russian Academy of Sciences, 3, Institutskaya st., Pushchino, 142290, Russia 
 Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3, Institutskaya st., Pushchino, 142290, Russia 
 OJSC Head Center for the Reproduction of Farm Animals, Moscow Region, Russia 
 Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3, Institutskaya st., Pushchino, 142290, Russia; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moskow, Russia 
 IAM RAS, 7, Leningradsky prt, 125040, Moscow, Russia 
 National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of Russian Federation, 4 Oparin str, 117997, Moscow, Russia 
Publication year
2020
Publication date
Jan 2020
Publisher
IOP Publishing
ISSN
17578981
e-ISSN
1757899X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2562036727
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.