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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

We investigated the effects of oral L-glutamine (Gln) supplementation, associated or not with physical exercises, in control of glycemia, oxidative stress, and strength/power of knee muscles in elderly women. Physically active (n = 21) and sedentary (n = 23) elderly women aged 60 to 80 years were enrolled in the study. Plasma levels of D-fructosamine, insulin, reduced (GSH) and oxidized (GSSG) glutathione, iron, uric acid, and thiobarbituric acid-reactive substances (TBARs) (lipoperoxidation product), as well as knee extensor/flexor muscle torque peak and average power (isokinetic test), were assessed pre- and post-supplementation with Gln or placebo (30 days). Higher plasma D-fructosamine, insulin, and iron levels, and lower strength/power of knee muscles were found pre-supplementation in the NPE group than in the PE group. Post-supplementation, Gln subgroups showed higher levels of GSH, GSSG, and torque peak, besides lower D-fructosamine than pre-supplementation values. Higher muscle average power and plasma uric acid levels were reported in the PE + Gln group, whereas lower insulin levels were found in the NPE + Gln than pre-supplementation values. TBARs levels were diminished post-supplementation in all groups. Gln supplementation, mainly when associated with physical exercises, improves strength and power of knee muscles and glycemia control, besides boosting plasma antioxidant capacity of elderly women.

Details

Title
L-Glutamine Supplementation Enhances Strength and Power of Knee Muscles and Improves Glycemia Control and Plasma Redox Balance in Exercising Elderly Women
Author
Amirato, Gislene R 1 ; Borges, Juliana O 1 ; Marques, Daniella L 1 ; Santos, Juliana M B 2   VIAFID ORCID Logo  ; Santos, Carlos A F 3   VIAFID ORCID Logo  ; Andrade, Marilia S 4   VIAFID ORCID Logo  ; Furtado, Guilherme E 5 ; Rossi, Marcelo 6 ; Luis, Lais N 1 ; Zambonatto, Raquel F 1 ; da Silva, Eliane B 1 ; Poma, Sarah O 1   VIAFID ORCID Logo  ; de Almeida, Mariana M 1 ; Pelaquim, Renato L 1   VIAFID ORCID Logo  ; dos Santos-Oliveira, Laiane C 1 ; Sousa Diniz, Vinicius L 1   VIAFID ORCID Logo  ; Passos, Maria E P 1 ; Levada-Pires, Adriana C 1 ; Gorjão, Renata 1 ; Barros, Marcelo P 1   VIAFID ORCID Logo  ; Bachi, André L L 7   VIAFID ORCID Logo  ; Pithon-Curi, Tania C 1 

 Interdisciplinary Post-Graduate Program in Health Sciences, Institute of Physical Activity Sciences and Sports (ICAFE), Cruzeiro do Sul University, São Paulo, SP 01506-000, Brazil; [email protected] (G.R.A.); [email protected] (J.O.B.); [email protected] (D.L.M.); [email protected] (L.N.L.); [email protected] (R.F.Z.); [email protected] (E.B.d.S.); [email protected] (S.O.P.); [email protected] (M.M.d.A.); [email protected] (R.L.P.); [email protected] (L.C.d.S.-O.); [email protected] (V.L.S.D.); [email protected] (M.E.P.P.); [email protected] (A.C.L.-P.); [email protected] (R.G.); [email protected] (T.C.P.-C.) 
 Post-Graduation Program in Science of Human and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP 11015-020, Brazil; [email protected] 
 Department of Medicine (Geriatrics and Gerontology), Federal University of São Paulo (UNIFESP), São Paulo, SP 04020-050, Brazil; [email protected] 
 Department of Physiology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-901, Brazil; [email protected] 
 Health Sciences Research Unit: Nursing (UICISA:E), Nursing School of Coimbra (ESEnfC), 3000-232 Coimbra, Portugal; [email protected] 
 Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo, SP 04829-300, Brazil; [email protected] (M.R.); [email protected] (A.L.L.B.) 
 Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo, SP 04829-300, Brazil; [email protected] (M.R.); [email protected] (A.L.L.B.); ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), São Paulo, SP 04023-062, Brazil 
First page
1025
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20726643
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2562156193
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.