Abstract

According to the US Endocrinology Society, vitamin D deficiency is defined as a 25(OH)D level of ≤ 20 ng/mL; insufficiency as 21 to 29 ng/mL; and sufficiency as > 30 ng/mL or more [15]. With few exceptions, these studies neither clearly support nor exclude the causal association of 25(OH)D levels with T2D [11, 29,30,31]. [...]these studies have examined mainly individuals from European populations, except one recent study included East Asians with Europeans [31]. [...]in this study, we, for the first time, have included data from South Asian Indians with Europeans. Research design and methods Ethical statement All participating studies were reviewed and approved by the respective Universities or Institutional Review Boards, including the primary institute of the University of Oklahoma Health Sciences Center’s Institutional Review Board, as well as the Human Subject Protection Committees at the participating hospitals and institutes in India.

Details

Title
A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans
Author
Bejar, Cynthia A; Goyal, Shiwali; Afzal, Shoaib; Mangino, Massimo; Zhou, Ang; Peter J. van der Most; Bao, Yanchun; Gupta, Vipin; Smart, Melissa C; Walia, Gagandeep K; Verweij, Niek; Power, Christine; Prabhakaran, Dorairaj; Jai Rup Singh; Mehra, Narinder K; Wander, Gurpreet S
Pages
1-11
Section
Research
Publication year
2021
Publication date
2021
Publisher
BioMed Central
e-ISSN
14752891
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2562529944
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.