Effect of Aloe Vera Gel Extract to The Physicochemical Properties and Effectiveness of Burn Cream Formulation

Abstract

Aloe chinensis Baker is commonly cultivated in Indonesia especially in Pontianak and Bogor. Aloe vera gel contains various anti-inflammatory compounds. The objectives of this study are to determine the effects of Aloe vera gel extract additions to the formulations of burn cream and to obtain the best formulation in healing burn wounds on outer epidermis through testing on white mice. Aloe vera gel extract was prepared with a rotary evaporator for 90 minutes at 40 °C and 110 mBar. The basic formulation of the burn cream included oil phase and water phase. There were six concentrations of Aloe vera gel extract added to the above burn cream at 0%, 2.5%, 5%, 7.5%, 10% and 12.5%. The resulting formulations produced pHs that were within the acceptable range of skin physiology (4-8). The viscosities were in good consistencies that were easily applied on skin without drips. They also exhibited fineness values of 9-10 μ, refractive indices ranging from 51.5 to 78.3, and opaque color of milky white. Biological experiments showed that burn cream sample with Aloe vera gel extract at 5% concentration to be the most effective by healing 2^nd degree burn wounds the fastest during 20-day trials.