Low 25(OH)D Serum May Not Reflect at Risk Skeletal Health but Not with Body Mass Index in Women

Abstract

Background: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D-binding protein (DBP). However, obese people have a higher bone mineral density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters. Objective:We sought to determine whether there is association between 25(OH)D 1) with bone health parameter differ by body weight; 2) Body mass index and BMD. Design: We conducted a cross-sectional observational study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight, and obese women subjects (15.2±4.9 ng/mL). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters and body weight, but there is an association between BMD and body weight (p<0.05). Conclusions: Serum total 25(OH))D lower at all categorize body mass index, which cannot be explained by higher in adipocyte and lower in circulation or low DBP or shorter half-life of 25(OH)D. Lower 25(OH)D may not reflect at risk skeletal helath and higher BMI should be considered as a marker of higher BMD.