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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The introduction of solid foods is an important dietary event during infancy that causes profound shifts in the gut microbial composition towards a more adult-like state. Infant gut bacterial dynamics, especially in relation to nutritional intake remain understudied. Over 2 weeks surrounding the time of solid food introduction, the day-to-day dynamics in the gut microbiomes of 24 healthy, full-term infants from the Baby, Food & Mi and LucKi-Gut cohort studies were investigated in relation to their dietary intake. Microbial richness (observed species) and diversity (Shannon index) increased over time and were positively associated with dietary diversity. Microbial community structure (Bray–Curtis dissimilarity) was determined predominantly by individual and age (days). The extent of change in community structure in the introductory period was negatively associated with daily dietary diversity. High daily dietary diversity stabilized the gut microbiome. Bifidobacterial taxa were positively associated, while taxa of the genus Veillonella, that may be the same species, were negatively associated with dietary diversity in both cohorts. This study furthers our understanding of the impact of solid food introduction on gut microbiome development in early life. Dietary diversity seems to have the greatest impact on the gut microbiome as solids are introduced.

Details

Title
Infants’ First Solid Foods: Impact on Gut Microbiota Development in Two Intercontinental Cohorts
Author
Chiara-Maria Homann 1 ; Rossel, Connor A J 2   VIAFID ORCID Logo  ; Dizzell, Sara 3 ; Bervoets, Liene 2 ; Simioni, Julia 4 ; Li, Jenifer 5 ; Gunn, Elizabeth 6 ; Surette, Michael G 7 ; de Souza, Russell J 8   VIAFID ORCID Logo  ; Mommers, Monique 9 ; Hutton, Eileen K 5 ; Morrison, Katherine M 6   VIAFID ORCID Logo  ; Penders, John 10   VIAFID ORCID Logo  ; Niels van Best 11   VIAFID ORCID Logo  ; Stearns, Jennifer C 7   VIAFID ORCID Logo 

 Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; [email protected] (C.-M.H.); [email protected] (S.D.); [email protected] (M.G.S.); Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada; [email protected] (E.G.); [email protected] (K.M.M.); Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4K1, Canada 
 Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands; [email protected] (C.A.J.R.); [email protected] (L.B.); [email protected] (J.P.) 
 Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; [email protected] (C.-M.H.); [email protected] (S.D.); [email protected] (M.G.S.) 
 Department of Obstetrics & Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada; [email protected] (J.S.); [email protected] (J.L.); [email protected] (E.K.H.) 
 Department of Obstetrics & Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada; [email protected] (J.S.); [email protected] (J.L.); [email protected] (E.K.H.); McMaster Midwifery Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada 
 Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada; [email protected] (E.G.); [email protected] (K.M.M.); Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON L8S 4K1, Canada 
 Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada; [email protected] (C.-M.H.); [email protected] (S.D.); [email protected] (M.G.S.); Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada 
 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON L8S 4K1, Canada; [email protected]; Population Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON L8L 2X2, Canada 
 Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University, 6229 ER Maastricht, The Netherlands; [email protected] 
10  Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands; [email protected] (C.A.J.R.); [email protected] (L.B.); [email protected] (J.P.); InVivo Planetary Health: An Affiliate of the World Universities Network (WUN), West New York, NJ 10704, USA; Department of Medical Microbiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands 
11  Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6229 ER Maastricht, The Netherlands; [email protected] (C.A.J.R.); [email protected] (L.B.); [email protected] (J.P.); InVivo Planetary Health: An Affiliate of the World Universities Network (WUN), West New York, NJ 10704, USA; Institute of Medical Microbiology, RWTH University Hospital Aachen, RWTH University, 52074 Aachen, Germany 
First page
2639
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20726643
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2565482267
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.