Abstract

Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.

Details

Title
Microglia have a grip on brain microvasculature
Author
Kisler Kassandra 1   VIAFID ORCID Logo  ; Nikolakopoulou, Angeliki Maria 1   VIAFID ORCID Logo  ; Zlokovic Berislav V 1   VIAFID ORCID Logo 

1  Keck School of Medicine of the University of Southern California, Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Los Angeles, USA (GRID:grid.42505.36) (ISNI:0000 0001 2156 6853) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-021-25595-3
ProQuest document ID
2569483146
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.