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Abstract
Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea’s inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear’s sensory epithelium in cadaveric human inner ears.
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1 Massachusetts Eye and Ear and Harvard Medical School, Department of Otolaryngology – Head and Neck Surgery, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Harvard University Graduate School of Arts and Sciences, Program in Speech and Hearing Bioscience and Technology, Cambridge, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924); Massachusetts General Hospital, Department of Pathology, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924)
2 Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924); Massachusetts General Hospital, Department of Pathology, Boston, USA (GRID:grid.32224.35) (ISNI:0000 0004 0386 9924)
3 Massachusetts Eye and Ear and Harvard Medical School, Department of Otolaryngology – Head and Neck Surgery, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Harvard University Graduate School of Arts and Sciences, Program in Speech and Hearing Bioscience and Technology, Cambridge, USA (GRID:grid.38142.3c) (ISNI:000000041936754X); Stanford University School of Medicine, Department of Otolaryngology – Head and Neck Surgery, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Massachusetts Eye and Ear and Harvard Medical School, Department of Otolaryngology – Head and Neck Surgery, Stanford, USA (GRID:grid.39479.30) (ISNI:0000 0000 8800 3003)