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Abstract
Rapid retrospective biodosimetry methods are essential for the fast triage of persons occupationally or accidentally exposed to ionizing radiation. Identification and detection of a radiation specific molecular ‘footprint’ should provide a sensitive and reliable measurement of radiation exposure. Here we discuss conventional (cytogenetic) methods of detection and assessment of radiation exposure in comparison to emerging approaches such as gene expression signatures and DNA damage markers. Furthermore, we provide an overview of technical and logistic details such as type of sample required, time for sample preparation and analysis, ease of use and potential for a high throughput analysis.
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Details
1 Radiation Oncology, Canberra Hospital, Garran, ACT, 2605, Australia; Australian National University, Canberra ACT 2600, Australia
2 Molecular Development, Murdoch Children’s Research Institute, Melbourne, VIC, 3052, Australia
3 Radiation Oncology, Canberra Hospital, Garran, ACT, 2605, Australia
4 Radiation Oncology, Canberra Hospital, Garran, ACT, 2605, Australia; College of Medicine Biology and Environment, Australian National University, Canberra ACT 2600, Australia