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Abstract
Myelin containing in basal ganglia in multiple sclerosis patients was evaluated using new noninvasive quantitative MRI method fast whole brain macromolecular proton fraction mapping. Myelin level in globus pallidus and putamen significantly decreased in multiple sclerosis patients as compared with healthy control subjects but not in substantia nigra and caudate nucleus.
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Details
1 Neurobiology Lab, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation
2 Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle, USA; Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA
3 Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA
4 Neurobiology Lab, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation; Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle, USA