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Abstract
Chemical dosimeters, including PRESAGE® as used in optical CT, exhibit significant quenching effects in response to proton irradiation and this may limit their widespread uptake. This study performs careful measurements of the observed quenching of a recently developed variant of PRESAGE® in a 60 MeV proton beam and uses them to attempt an empirical correction of a simple superposition of two unmodulated beams.
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1 CRUK Cancer Imaging Centre, Institute of Cancer Research, London, UK; University of Surrey, Guildford, UK
2 Institute of Medical Physics, School of Physics, University of Sydney, NSW 2006, Australia
3 Department of Chemistry and Biology, Rider University, Lawrenceville, NJ, USA; Heuris Pharma, LLC, 412 Sunset Rd., Skillman, NJ, 08558 USA
4 Douglas Cyclotron, Clatterbridge Centre for Oncology, Wirral, UK