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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

Details

Title
The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles
Author
Xu, Haixia 1 ; Xu, Xizi 1 ; Li, Siyu 1 ; Wen-Liang, Song 1 ; Deng-Guang Yu 2   VIAFID ORCID Logo  ; Bligh, S W Annie 3   VIAFID ORCID Logo 

 School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; [email protected] (H.X.); [email protected] (X.X.); [email protected] (S.L.); [email protected] (W.-L.S.) 
 School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; [email protected] (H.X.); [email protected] (X.X.); [email protected] (S.L.); [email protected] (W.-L.S.); Shanghai Engineering Technology Research Center for High-Performance Medical Device Materials, Shanghai 200093, China 
 School of Health Sciences, Caritas Institute of Higher Education, Hong Kong 999077, China 
First page
1330
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
2218273X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2576382181
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.