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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Skeletal muscle mass reduction has been implicated in insulin resistance (IR) that promotes cardiometabolic diseases. We have previously reported that arsenic exposure increases IR concomitantly with the reduction of skeletal muscle mass among individuals exposed to arsenic. The arsenic methylation capacity is linked to the susceptibility to some arsenic exposure-related diseases. However, it remains unknown whether the arsenic methylation capacity affects the arsenic-induced reduction of muscle mass and elevation of IR. Therefore, this study examined the associations between the arsenic methylation status and skeletal muscle mass measures with regard to IR by recruiting 437 participants from low- and high-arsenic exposure areas in Bangladesh. The subjects’ skeletal muscle mass was estimated by their lean body mass (LBM) and serum creatinine levels. Subjects’ drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI). Subjects’ LBM and serum creatinine levels were positively associated with the percentage of DMA and SMI, as well as inversely associated with the percentage of MMA. HOMA-IR showed an inverse association with SMI, with a confounding effect of sex. Our results suggest that reduced secondary methylation capacity is involved in the arsenic-induced skeletal muscle loss that may be implicated in arsenic-induced IR and cardiometabolic diseases.

Details

Title
Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction
Author
Md Khalequzzaman Sarker 1 ; Selim Reza Tony 2   VIAFID ORCID Logo  ; Siddique, Abu Eabrahim 2   VIAFID ORCID Logo  ; Karim, Md Rezaul 3 ; Haque, Nazmul 2 ; Islam, Zohurul 2 ; Islam, Md Shofikul 3 ; Khatun, Moriom 2 ; Islam, Jahidul 2 ; Hossain, Shakhawoat 2 ; Zahangir Alam Saud 2 ; Miyataka, Hideki 4 ; Sumi, Daigo 4   VIAFID ORCID Logo  ; Barchowsky, Aaron 5 ; Himeno, Seiichiro 6   VIAFID ORCID Logo  ; Hossain, Khaled 2 

 Institute of Biological Sciences, University of Rajshahi, Rajshahi 6205, Bangladesh; [email protected] 
 Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh; [email protected] (S.R.T.); [email protected] (A.E.S.); [email protected] (N.H.); [email protected] (Z.I.); [email protected] (M.K.); [email protected] (J.I.); [email protected] (S.H.); [email protected] (Z.A.S.) 
 Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, Bangladesh; [email protected] (M.R.K.); [email protected] (M.S.I.) 
 Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan; [email protected] (H.M.); [email protected] (D.S.); [email protected] (S.H.) 
 Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; [email protected] 
 Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan; [email protected] (H.M.); [email protected] (D.S.); [email protected] (S.H.); Division of Health Chemistry, School of Pharmacy, Showa University, Tokyo 142-8555, Japan 
First page
9730
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
1661-7827
e-ISSN
1660-4601
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2576424207
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.