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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Periodontal disease is the most common oral chronic inflammatory disease in humans. Recent studies have indicated that red light Photobiomodulation (PBM) could inhibit cell inflammation effectively, but the effect of different doses of PBM on the treatment of inflammation has to be improved. Thus, this study was aimed to investigate the effects of various doses of PBM (630 ± 30 nm, (1) 5 mW/cm2, 1 J/cm2, 200 s; (2) 5 mW/cm2, 3 J/cm2, 600 s; (3) 5 mW/cm2, 9 J/cm2, 1800 s; (4) 5 mW/cm2, 18 J/cm2, 3600 s; (5) 5 mW/cm2,36 J/cm2, 7200 s) on the anti-inflammatory response of human gingival fibroblasts. Our results suggested that PBM (630 ± 30 nm) with doses of 18 J/cm2 and 36 J/cm2 could significantly inhibit the production of inflammatory cytokines such as Prostaglandin E2 (PGE2) and IL-8, presumably due to the fact that a high dose of PBM treatment could reduce intracellular Reactive oxygen species (ROS) in human gingival fibroblasts, thus reducing the expression of COX-2 enzyme. In addition, it was found that treatment with different doses of PBM (630 ± 30 nm) did not result in reduced mitochondrial membrane potential and mitochondrial dysfunction in human gingival fibroblasts. Our study provides a theoretical reference for the selection of PBM parameters and the application of PBM in the clinical treatment of periodontitis.

Details

Title
The Effect of 630 nm Photobiomodulation on the Anti-Inflammatory Effect of Human Gingival Fibroblasts
Author
Chen, Zeqing 1 ; Liu, Xuwen 2 ; Qin, Haokuan 3 ; Lu, Zhicheng 3 ; Huang, Shijie 2   VIAFID ORCID Logo  ; Liu, Muqing 4   VIAFID ORCID Logo 

 Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China; [email protected]; Qingdao Municipal Health Commission, Qingdao 266071, China; Institute of Future Lighting, Academy for Engineering & Technology, Fudan University, 220th Handan Road, Shanghai 200433, China; [email protected] (H.Q.); [email protected] (Z.L.) 
 Institute for Electric Light Sources, Fudan University, 220th Handan Road, Shanghai 200433, China; [email protected] (X.L.); [email protected] (S.H.) 
 Institute of Future Lighting, Academy for Engineering & Technology, Fudan University, 220th Handan Road, Shanghai 200433, China; [email protected] (H.Q.); [email protected] (Z.L.) 
 Institute of Future Lighting, Academy for Engineering & Technology, Fudan University, 220th Handan Road, Shanghai 200433, China; [email protected] (H.Q.); [email protected] (Z.L.); Institute for Electric Light Sources, Fudan University, 220th Handan Road, Shanghai 200433, China; [email protected] (X.L.); [email protected] (S.H.); Zhongshan Fudan Joint Innovation Center, 6th Xiangxing Road, Zhongshan 528403, China 
First page
360
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
23046732
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2576482443
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.