Abstract

Biological models of an apoptotic process are studied using models describing a system of differential equations derived from reaction kinetics information. The mathematical model is re-formulated in a state-space robust control theory framework where parametric and dynamic uncertainty can be modelled to account for variations naturally occurring in biological processes. We propose to handle the nonlinearities using neural networks.

Details

Title
Applying robust control theory to solve problems in bio-medical sciences: study of an apoptotic model
Author
Trujillo, M 1 ; Becerra, V M 2 ; Hadjiloucas, S 2 

 To whom any correspondence should be addressed 
 School of Systems Engineering, University of Reading, RG6 6AY, UK 
Publication year
2014
Publication date
Mar 2014
Publisher
IOP Publishing
ISSN
17426588
e-ISSN
17426596
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2576599527
Copyright
© 2014. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.