Parametry immunologiczne a wyniki testów czynnościowych płuc w niektórych chorobach płuc przebiegających ze zwłóknieniem

Abstract

Praca przedstawia wyniki badań immunologicznych i czynnościowych u pacjentów z chorobami śródmiąższowymi płuc.

Alternate abstract:

The objective of the study was the evaluation of the differences in diffusion capacity and spirometric test in patients with selected parenchymal lung diseases, and determination of the relationship observed in immune profile at the site of pathological process in progress with changes in lung function. Parenchymal lung disease was diagnosed in a group of 25 patients based on clinical, radiologic and histopathologic examinations. In addition, spirometric test was performed, and single-breath carbon monoxide diffusing capacity (DLCO) with the measurement of the total diffusing capacity of the whole lung and residual volume by the method of He dilution. In all the patients examined bronchoscopy was also performed with bronchoalveolar lavage, and the analysis of leukocyte phenotypes in bronchoalveolar lavage fluid by means of monoclonal antibodies with the use of flow cytometer. For all the groups analysed a statistically significant relationship was noted between the type of parenchymal disease diagnosed and reduction in lung diffusion capacity. In addition, significant positive correlations were confirmed between the percentage of macrophages in bronchoalveolar lavage fluid and alveolar flow, and between the percentage of T-helper lymphocytes and maximum expiratory flow.