Abstract

Delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria and a semiautomatic approach to obtain transmural scar maps in ventricular models reconstructed from both 3D-acquired and 3D-upsampled-2D-acquired LGE-CMR images. The results showed that 3D-upsampled models from 2D LGE-CMR images provided a time-efficient alternative to 3D-acquired sequences to assess the myocardial substrate associated with ischemic cardiomyopathy. Scar assessment from 2D-LGE-CMR sequences using 3D-upsampled models was superior to conventional 2D assessment to identify scar sizes associated with the cycle length of spontaneous ventricular tachycardia episodes and long-term ventricular tachycardia recurrences after catheter ablation. This novel methodology may represent an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D LGE-CMR slices and automatic scar detection.

Details

Title
Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
Author
Merino-Caviedes Susana 1 ; Gutierrez, Lilian K 2 ; Alfonso-Almazán, José Manuel 2 ; Sanz-Estébanez, Santiago 1 ; Cordero-Grande Lucilio 3 ; Quintanilla, Jorge G 4 ; Sánchez-González, Javier 5 ; Marina-Breysse, Manuel 6 ; Galán-Arriola, Carlos 6 ; Enríquez-Vázquez, Daniel 7 ; Torres, Carlos 8 ; Pizarro Gonzalo 9 ; Ibáñez Borja 10 ; Peinado, Rafael 11 ; Merino, Jose Luis 11 ; Pérez-Villacastín Julián 12 ; Jalife José 6 ; López-Yunta Mariña 13 ; Vázquez Mariano 14 ; Aguado-Sierra Jazmín 13 ; González-Ferrer, Juan José 15 ; Pérez-Castellano Nicasio 12 ; Martín-Fernández Marcos 1 ; Alberola-López, Carlos 1 ; Filgueiras-Rama, David 4 

 University of Valladolid, Laboratorio de Procesado de Imagen, Valladolid, Spain (GRID:grid.5239.d) (ISNI:0000 0001 2286 5329) 
 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Madrid, Spain (GRID:grid.467824.b) (ISNI:0000 0001 0125 7682) 
 Universidad Politécnica de Madrid, Biomedical Image Technologies, ETSI Telecomunicación, Madrid, Spain (GRID:grid.5690.a) (ISNI:0000 0001 2151 2978); Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427) 
 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Madrid, Spain (GRID:grid.467824.b) (ISNI:0000 0001 0125 7682); Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain (GRID:grid.414780.e); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (GRID:grid.510932.c) 
 Philips Healthcare Iberia, Madrid, Spain (GRID:grid.510932.c) 
 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Madrid, Spain (GRID:grid.467824.b) (ISNI:0000 0001 0125 7682); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (GRID:grid.510932.c) 
 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Madrid, Spain (GRID:grid.467824.b) (ISNI:0000 0001 0125 7682); Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain (GRID:grid.414780.e) 
 Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain (GRID:grid.414780.e) 
 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Madrid, Spain (GRID:grid.467824.b) (ISNI:0000 0001 0125 7682); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (GRID:grid.510932.c); Cardiology Department, Hospital Ruber Juan Bravo Quironsalud UEM, Madrid, Spain (GRID:grid.510932.c) 
10  Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Madrid, Spain (GRID:grid.467824.b) (ISNI:0000 0001 0125 7682); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (GRID:grid.510932.c); Cardiology Department, IIS-University Hospital Fundación Jiménez Díaz, Madrid, Spain (GRID:grid.476442.7) 
11  Hospital Universitario La Paz, Cardiology Department, Madrid, Spain (GRID:grid.81821.32) (ISNI:0000 0000 8970 9163) 
12  Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain (GRID:grid.414780.e); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (GRID:grid.510932.c); Fundación Interhospitalaria para la Investigación Cardiovascular (FIC), Madrid, Spain (GRID:grid.490176.d) 
13  Barcelona Supercomputing Center (BSC), Barcelona, Spain (GRID:grid.10097.3f) (ISNI:0000 0004 0387 1602) 
14  Barcelona Supercomputing Center (BSC), Barcelona, Spain (GRID:grid.10097.3f) (ISNI:0000 0004 0387 1602); ELEM Biotech SL., Barcelona, Spain (GRID:grid.10097.3f) 
15  Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain (GRID:grid.414780.e); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (GRID:grid.510932.c) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2576737972
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.