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Abstract
Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis and widely used over the years. However, a systematic analysis of the accumulated results has not been performed. We undertook a comprehensive data mining and subsequent manual curation, resulting in a collection of 213 genes (available at the TiRe database, www.tiredb.org), which when manipulated had a clear impact on bleomycin-induced lung fibrosis. Our meta-analysis highlights the age component in pulmonary fibrosis and strong links of related genes with longevity. The results support the validity of the bleomycin model to human pathology and suggest the importance of a multi-target therapeutic strategy for pulmonary fibrosis treatment.
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1 Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Beer-Sheva, Israel (GRID:grid.7489.2) (ISNI:0000 0004 1937 0511); Institute of Biochemistry of the Romanian Academy, Systems Biology of Aging Group, Bucharest, Romania (GRID:grid.418333.e) (ISNI:0000 0004 1937 1389)
2 National Institute on Aging, NIH, Epigenetics and Stem Cell Unit, Translational Gerontology Branch, Baltimore, USA (GRID:grid.419475.a) (ISNI:0000 0000 9372 4913)
3 Ben-Gurion University of the Negev, The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Beer-Sheva, Israel (GRID:grid.7489.2) (ISNI:0000 0004 1937 0511)
4 Institute of Biochemistry of the Romanian Academy, Systems Biology of Aging Group, Bucharest, Romania (GRID:grid.418333.e) (ISNI:0000 0004 1937 1389)
5 Medical University of Vienna, Internal Medicine II/Pulmonology, Wien, Austria (GRID:grid.22937.3d) (ISNI:0000 0000 9259 8492)