It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hypothesized that increased concentrations of combustion related PM would result in dysregulation of the innate immune system. This epidemiological study includes 111 adult patients hospitalized with respiratory infections who underwent transcriptional analysis of their peripheral blood. We examined the association between gene expression at the time of hospitalization and ambient measurements of particulate air pollutants in the 28 days prior to hospitalization. For each pollutant and time lag, gene-specific linear models adjusting for infection type were fit using LIMMA (Linear Models For Microarray Data), and pathway/gene set analyses were performed using the CAMERA (Correlation Adjusted Mean Rank) program. Comparing patients with viral and/or bacterial infection, the expression patterns associated with air pollution exposure differed. Adjusting for the type of infection, increased concentrations of Delta-C (a marker of biomass smoke) and other PM were associated with upregulation of iron homeostasis and protein folding. Increased concentrations of black carbon (BC) were associated with upregulation of viral related gene pathways and downregulation of pathways related to antigen presentation. The pollutant/pathway associations differed by lag time and by type of infection. This study suggests that the effect of air pollution on the pathogenesis of respiratory infection may be pollutant, timing, and infection specific.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 University of Rochester Medical Center, Department of Medicine, Pulmonary and Critical Care Medicine Division, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Environmental Health Science Center, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
2 University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
3 University of Rochester Medical Center, Environmental Health Science Center, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Pediatrics, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
4 University of Rochester Medical Center, Department of Medicine, Infectious Diseases Division, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
5 University of Rochester Medical Center, Environmental Health Science Center, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Public Health Sciences, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); Clarkson University, Institute for a Sustainable Environment, and Center for Air Resources Engineering and Science, Potsdam, USA (GRID:grid.254280.9) (ISNI:0000 0001 0741 9486)
6 University of Rochester Medical Center, Environmental Health Science Center, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Pediatrics, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Biomedical Genetics, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
7 University of Rochester Medical Center, Department of Medicine, Pulmonary and Critical Care Medicine Division, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Environmental Health Science Center, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Pediatrics, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Public Health Sciences, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
8 University of Rochester Medical Center, Department of Public Health Sciences, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)
9 University of Rochester Medical Center, Environmental Health Science Center, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166); University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, USA (GRID:grid.412750.5) (ISNI:0000 0004 1936 9166)