Abstract

This study aims to quantitatively investigate the optical coherence tomographic angiography (OCTA) findings of capillary congestion and its association with macular edema (ME) recurrence in chronic branch retinal vein occlusion (BRVO). We retrospectively reviewed the medical records of 115 consecutive patients with major ischemic BRVO who reached stable macula (without ME for two consecutive visits) at baseline (the first visit within the stable period). All patients were classified into a recurrence or non-recurrence groups depending on ME recurrence. Capillary congestion of deep capillary plexuses (DCP-C) and other abnormal capillary lesions were segmented, and their areas, vascular densities, and mean retinal thicknesses (MRT) were calculated. The main outcomes were differences between the two groups and risk factors for recurrence among baseline and OCTA parameters. A total of 76 eyes were included, of which 22 (28.9%) recurred. DCP-C existed in all eyes at baseline. MRT of DCP-C (p = 0.006) was greater in the recurrence group. Greater MRT of DCP-C (OR: 1.044; p = 0.002) and more frequent intravitreal injections (OR: 1.803; p < 0.001) were associated with a higher risk of relapsing ME. DCP-C may contribute to the anatomical stability of chronic BRVO and simultaneously be the source of ME.

Details

Title
Association between capillary congestion and macular edema recurrence in chronic branch retinal vein occlusion through quantitative analysis of OCT angiography
Author
Kang, Min Seung 1 ; Yoon, Kim Sang 1 ; Park Sung Who 2 ; Byon Ik Soo 2 ; Kwon, Han Jo 1 

 Pusan National University Yangsan Hospital, Department of Ophthalmology, Yangsan-si, South Korea (GRID:grid.412591.a) (ISNI:0000 0004 0442 9883); Pusan National University Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology, Yangsan-si, South Korea (GRID:grid.412591.a) (ISNI:0000 0004 0442 9883) 
 Pusan National University School of Medicine, Yangsan-si, South Korea (GRID:grid.262229.f) (ISNI:0000 0001 0719 8572); Pusan National University Hospital, Department of Ophthalmology, Biomedical Research Institute, Busan, South Korea (GRID:grid.412588.2) (ISNI:0000 0000 8611 7824) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2579465734
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.