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Abstract
Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.
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1 Vall d’Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain (GRID:grid.411083.f) (ISNI:0000 0001 0675 8654); Instituto René Rachou-FIOCRUZ Minas, Belo Horizonte, Brazil (GRID:grid.411083.f)
2 Universidade Federal de Minas Gerais, Department of Internal Medicine, Medical School and Telehealth Center, University Hospital, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888); Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f)
3 Universidade Federal de Minas Gerais, Department of Statistics, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888)
4 Hospital Marcio Cunha, Ipatinga, Brazil (GRID:grid.8430.f)
5 Universidade Federal de Minas Gerais, Medical School, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888)
6 Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f)
7 Hospital UNIMED BH, Belo Horizonte, Brazil (GRID:grid.8430.f)
8 Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil (GRID:grid.8430.f); Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.419130.e) (ISNI:0000 0004 0413 0953)
9 Hospital Regional Antônio Dias, Patos de Minas, Brazil (GRID:grid.419130.e)
10 Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil (GRID:grid.419130.e); Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.419130.e) (ISNI:0000 0004 0413 0953)
11 Hospital Risoleta Tolentino Neves, Belo Horizonte, Brazil (GRID:grid.490178.3)
12 Hospital João XXIII, Belo Horizonte, Brazil (GRID:grid.490178.3)
13 Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (GRID:grid.414449.8) (ISNI:0000 0001 0125 3761)
14 Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Porto Alegre, Brazil (GRID:grid.414914.d); Hospital Nossa Senhora da Conceição, Grupo Hospitalar Conceição, Porto Alegre, Brazil (GRID:grid.414914.d)
15 Universidade Federal de Minas Gerais, Medical School, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888); Hospital Julia Kubitschek, Belo Horizonte, Brazil (GRID:grid.8430.f)
16 Universidade Federal de Minas Gerais, Medical School, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888); Universidade Federal de Minas Gerais, Internal Medicine Department, University Hospital, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888)
17 Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.490178.3); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (GRID:grid.414449.8) (ISNI:0000 0001 0125 3761)
18 Universidade do Vale do Taquari (UNIVATES), Lajeado, Brazil (GRID:grid.441846.b) (ISNI:0000 0000 9020 9633); Hospital Bruno Born, Lajeado, Brazil (GRID:grid.441846.b)
19 Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f); Universidade Federal de Minas Gerais, Center for Research and Graduate Studies in Business Administration, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888)
20 Hospital Regional Antônio Dias, Patos de Minas, Brazil (GRID:grid.441846.b); Centro Universitário de Patos de Minas, Patos de Minas, Brazil (GRID:grid.441942.e) (ISNI:0000 0004 0490 8155)
21 Hospital Eduardo de Menezes, Belo Horizonte, Brazil (GRID:grid.452464.5) (ISNI:0000 0000 9270 1314)
22 Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil (GRID:grid.452464.5)
23 Hospital Julia Kubitschek, Belo Horizonte, Brazil (GRID:grid.452464.5); Pontífica Universidade Católica de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.452464.5)
24 Hospital Julia Kubitschek, Belo Horizonte, Brazil (GRID:grid.414914.d); Pontífica Universidade Católica de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.414914.d)
25 Hospital Bruno Born, Lajeado, Brazil (GRID:grid.414914.d)
26 Medical School of Fundação Educacional do Município de Assis, Assis, Brazil (GRID:grid.8430.f)
27 Hospital Balbino - Rede D`or São Luiz, Rio de Janeiro, Brazil (GRID:grid.8430.f)
28 Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (GRID:grid.414449.8) (ISNI:0000 0001 0125 3761); Universidade Federal do Rio Grande do Sul, Internal Medicine Department, Porto Alegre, Brazil (GRID:grid.8532.c) (ISNI:0000 0001 2200 7498)