Abstract

Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.

Details

Title
Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes
Author
Molina, Israel 1   VIAFID ORCID Logo  ; Marcolino Milena Soriano 2   VIAFID ORCID Logo  ; Pires, Magda Carvalho 3   VIAFID ORCID Logo  ; Ramos Lucas Emanuel Ferreira 3   VIAFID ORCID Logo  ; Silva, Rafael Tavares 3   VIAFID ORCID Logo  ; Guimarães-Júnior, Milton Henriques 4   VIAFID ORCID Logo  ; de Oliveira Isaias José Ramos 5   VIAFID ORCID Logo  ; de Carvalho Rafael Lima Rodrigues 6   VIAFID ORCID Logo  ; Nunes Aline Gabrielle Sousa 7   VIAFID ORCID Logo  ; de Barros Ana Lara Rodrigues Monteiro 8   VIAFID ORCID Logo  ; Scotton Ana Luiza Bahia Alves 9   VIAFID ORCID Logo  ; Madureira Angélica Aparecida Coelho 10   VIAFID ORCID Logo  ; Farace, Bárbara Lopes 11   VIAFID ORCID Logo  ; de Carvalho Cíntia Alcantara 12   VIAFID ORCID Logo  ; Rodrigues Fernanda d’Athayde 13   VIAFID ORCID Logo  ; Anschau Fernando 14   VIAFID ORCID Logo  ; Botoni, Fernando Antonio 15   VIAFID ORCID Logo  ; Nascimento Guilherme Fagundes 7   VIAFID ORCID Logo  ; Duani Helena 16   VIAFID ORCID Logo  ; Guimarães Henrique Cerqueira 11   VIAFID ORCID Logo  ; de Alvarenga Joice Coutinho 12   VIAFID ORCID Logo  ; Moreira, Leila Beltrami 17   VIAFID ORCID Logo  ; Zandoná Liege Barella 18   VIAFID ORCID Logo  ; de Almeida Luana Fonseca 5   VIAFID ORCID Logo  ; Oliveira, Luana Martins 19   VIAFID ORCID Logo  ; Kopittke Luciane 14   VIAFID ORCID Logo  ; de Castro Luís César 18   VIAFID ORCID Logo  ; Santos Luisa Elem Almeida 20   VIAFID ORCID Logo  ; de Souza Cabral Máderson Alvares 16   VIAFID ORCID Logo  ; Ferreira Maria Angélica Pires 13   VIAFID ORCID Logo  ; da Cunha Severino Sampaio Natália 21   VIAFID ORCID Logo  ; de Oliveira Neimy Ramos 21   VIAFID ORCID Logo  ; Assaf Pedro Ledic 22   VIAFID ORCID Logo  ; Lopes Sofia Jarjour Tavares Starling 23   VIAFID ORCID Logo  ; Oliveira, Fereguetti Tatiani 21   VIAFID ORCID Logo  ; dos Santos Veridiana Baldon 14   VIAFID ORCID Logo  ; de Carvalho Victor Eliel Bastos 24   VIAFID ORCID Logo  ; Ramires Yuri Carlotto 25   VIAFID ORCID Logo  ; Ribeiro Antonio Luiz Pinho 2   VIAFID ORCID Logo  ; Moscoso Freddy Antonio Brito 26   VIAFID ORCID Logo  ; Moura Rogério 27 ; Polanczyk Carísi Anne 28   VIAFID ORCID Logo  ; do Carmo Pereira Nunes Maria 16   VIAFID ORCID Logo 

 Vall d’Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain (GRID:grid.411083.f) (ISNI:0000 0001 0675 8654); Instituto René Rachou-FIOCRUZ Minas, Belo Horizonte, Brazil (GRID:grid.411083.f) 
 Universidade Federal de Minas Gerais, Department of Internal Medicine, Medical School and Telehealth Center, University Hospital, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888); Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f) 
 Universidade Federal de Minas Gerais, Department of Statistics, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888) 
 Hospital Marcio Cunha, Ipatinga, Brazil (GRID:grid.8430.f) 
 Universidade Federal de Minas Gerais, Medical School, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888) 
 Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f) 
 Hospital UNIMED BH, Belo Horizonte, Brazil (GRID:grid.8430.f) 
 Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil (GRID:grid.8430.f); Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.419130.e) (ISNI:0000 0004 0413 0953) 
 Hospital Regional Antônio Dias, Patos de Minas, Brazil (GRID:grid.419130.e) 
10  Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil (GRID:grid.419130.e); Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.419130.e) (ISNI:0000 0004 0413 0953) 
11  Hospital Risoleta Tolentino Neves, Belo Horizonte, Brazil (GRID:grid.490178.3) 
12  Hospital João XXIII, Belo Horizonte, Brazil (GRID:grid.490178.3) 
13  Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (GRID:grid.414449.8) (ISNI:0000 0001 0125 3761) 
14  Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Porto Alegre, Brazil (GRID:grid.414914.d); Hospital Nossa Senhora da Conceição, Grupo Hospitalar Conceição, Porto Alegre, Brazil (GRID:grid.414914.d) 
15  Universidade Federal de Minas Gerais, Medical School, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888); Hospital Julia Kubitschek, Belo Horizonte, Brazil (GRID:grid.8430.f) 
16  Universidade Federal de Minas Gerais, Medical School, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888); Universidade Federal de Minas Gerais, Internal Medicine Department, University Hospital, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888) 
17  Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.490178.3); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (GRID:grid.414449.8) (ISNI:0000 0001 0125 3761) 
18  Universidade do Vale do Taquari (UNIVATES), Lajeado, Brazil (GRID:grid.441846.b) (ISNI:0000 0000 9020 9633); Hospital Bruno Born, Lajeado, Brazil (GRID:grid.441846.b) 
19  Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f); Universidade Federal de Minas Gerais, Center for Research and Graduate Studies in Business Administration, Belo Horizonte, Brazil (GRID:grid.8430.f) (ISNI:0000 0001 2181 4888) 
20  Hospital Regional Antônio Dias, Patos de Minas, Brazil (GRID:grid.441846.b); Centro Universitário de Patos de Minas, Patos de Minas, Brazil (GRID:grid.441942.e) (ISNI:0000 0004 0490 8155) 
21  Hospital Eduardo de Menezes, Belo Horizonte, Brazil (GRID:grid.452464.5) (ISNI:0000 0000 9270 1314) 
22  Hospital Metropolitano Doutor Célio de Castro, Belo Horizonte, Brazil (GRID:grid.452464.5) 
23  Hospital Julia Kubitschek, Belo Horizonte, Brazil (GRID:grid.452464.5); Pontífica Universidade Católica de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.452464.5) 
24  Hospital Julia Kubitschek, Belo Horizonte, Brazil (GRID:grid.414914.d); Pontífica Universidade Católica de Minas Gerais, Belo Horizonte, Brazil (GRID:grid.414914.d) 
25  Hospital Bruno Born, Lajeado, Brazil (GRID:grid.414914.d) 
26  Medical School of Fundação Educacional do Município de Assis, Assis, Brazil (GRID:grid.8430.f) 
27  Hospital Balbino - Rede D`or São Luiz, Rio de Janeiro, Brazil (GRID:grid.8430.f) 
28  Institute for Health Technology Assessment (IATS/ CNPq), Porto Alegre, Brazil (GRID:grid.8430.f); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (GRID:grid.414449.8) (ISNI:0000 0001 0125 3761); Universidade Federal do Rio Grande do Sul, Internal Medicine Department, Porto Alegre, Brazil (GRID:grid.8532.c) (ISNI:0000 0001 2200 7498) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2581619240
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.