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Abstract
Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be due to variation in the capacity to manage a nutritional load. We examined the genomic basis of postprandial metabolism. Our main purpose was to introduce the GEMM Family Study (Genetics of Metabolic Diseases in Mexico) as a multi-center study carrying out an ongoing recruitment of healthy urban adults. Each participant received a mixed meal challenge and provided a 5-hours’ time course series of blood, buffy coat specimens for DNA isolation, and adipose tissue (ADT)/skeletal muscle (SKM) biopsies at fasting and 3 h after the meal. A comprehensive profiling, including metabolomic signatures in blood and transcriptomic and proteomic profiling in SKM and ADT, was performed to describe tendencies for variation in postprandial response. Our data generation methods showed preliminary trends indicating that by characterizing the dynamic properties of biomarkers with metabolic activity and analyzing multi-OMICS data it could be possible, with this methodology and research design, to identify early trends for molecular biology systems and genes involved in the fasted and fed states.
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1 Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78227-0549, USA
2 Escuela de Ciencias de la Salud, Universidad Marista de Mérida, Mérida 97300, Mexico
3 Facultad de Salud Pública y Nutrición (FASPyN), UANL, Monterrey 64460, Mexico
4 Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, Mexico
5 Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78240, Mexico
6 Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac Norte, Lomas Anahuac 52786, Mexico
7 Facultad de Enfermería, Universidad Autónoma de Nuevo León (UANL), Monterrey 64460, Mexico
8 Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Ciudad de México C.P. 14610, Mexico
9 Departamento de Enseñanza, Postgrado e Investigación, Hospital Infantil de Tamaulipas, Ciudad Victoria 87150, Mexico
10 Departamento de Nutrición Humana, Universidad Latina de América, Morelia, Michoacán 58170, Mexico
11 Clínica de Enfermedades Crónicas y Procedimientos Especiales (CECYPE), Morelia 58249, Mexico
12 Universidad del Valle de Atemajac (UNIVA), Zapopan, Jalisco 45050, Mexico
13 Facultad de Medicina, Universidad Autónoma Estado de Morelos, Cuernavaca 62209, Mexico
14 Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz 91700, Mexico
15 Department of Medicine, Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA
16 Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA