Abstract

Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is limited. The aim of this study is to investigate the pharmacokinetic properties of ATBC using liquid chromatography–tandem mass spectrometric (LC–MS/MS) analysis. ATBC was rapidly absorbed and eliminated and the bioavailability was 27.4% in rats. The results of metabolic stability tests revealed that metabolic clearance may have accounted for a considerable portion of the total clearance of ATBC. These pharmacokinetic data would be useful in studies investigating the safety and toxicity of ATBC.

Details

Title
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Author
Kim, Hyeon 1 ; Min Sun Choi 1 ; Ji, Young Seok 1 ; In Sook Kim 1 ; Kim, Gi Beom 1 ; In Yong Bae 1 ; Myung Chan Gye 2 ; Yoo, Hye Hyun 1   VIAFID ORCID Logo 

1  Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Korea 
2  Department of Life Science, Institute of Natural Sciences, Hanyang University, Seoul 04763, Korea 
First page
177
Publication year
2018
Publication date
2018
Publisher
MDPI AG
e-ISSN
19994923
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.3390/pharmaceutics10040177
ProQuest document ID
2582830994
Copyright
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.