Abstract

In our previous study, all Arthrinium isolates from Sargassum sp. showed high bioactivities, but studies on marine Arthrinium spp. are insufficient. In this study, a phylogenetic analysis of 28 Arthrinium isolates from seaweeds and egg masses of Arctoscopus japonicus was conducted using internal transcribed spacers, nuclear large subunit rDNA, β-tubulin, and translation elongation factor region sequences, and their bioactivities were investigated. They were analyzed as 15 species, and 11 of them were found to be new species. Most of the extracts exhibited radical-scavenging activity, and some showed antifungal activities, tyrosinase inhibition, and quorum sensing inhibition. It was implied that marine algicolous Arthrinium spp. support the regulation of reactive oxygen species in symbiotic algae and protect against pathogens and bacterial biofilm formation. The antioxidant from Arthrinium sp. 10 KUC21332 was separated by bioassay-guided isolation and identified to be gentisyl alcohol, and the antioxidant of Arthrinium saccharicola KUC21221 was identical. These results demonstrate that many unexploited Arthrinium species still exist in marine environments and that they are a great source of bioactive compounds.

Details

Title
Diversity and Ecology of Marine Algicolous Arthrinium Species as a Source of Bioactive Natural Products
Author
Young Mok Heo 1 ; Kim, Kyeongwon 1 ; Seung Mok Ryu 2 ; Sun Lul Kwon 1 ; Min Young Park 2 ; Kang, Ji Eun 2 ; Joo-Hyun, Hong 1 ; Lim, Young Woon 3 ; Kim, Changmu 4 ; Kim, Beom Seok 2 ; Lee, Dongho 2 ; Jae-Jin, Kim 1   VIAFID ORCID Logo 

1  Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea 
2  Division of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea 
3  School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Korea 
4  Microorganism Resources Division, National Institute of Biological Resources, Incheon 22689, Korea 
First page
508
Publication year
2018
Publication date
2018
Publisher
MDPI AG
e-ISSN
16603397
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.3390/md16120508
ProQuest document ID
2582836021
Copyright
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.