Full text

Turn on search term navigation

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to improve cancer therapy. Several research works have highlighted the synthesis of gold and silver nanoparticles by green chemistry, using biological entities to minimize the use of solvents and control their physicochemical and biological properties. Recent advances in evaluating the anticancer effect of green biogenic Au and Ag nanoparticles are mainly focused on the use of conventional 2D cell culture and in vivo murine models that allow determination of the half-maximal inhibitory concentration, a critical parameter to move forward clinical trials. However, the interaction between nanoparticles and the tumor microenvironment is not yet fully understood. Therefore, it is necessary to develop more human-like evaluation models or to improve the existing ones for a better understanding of the molecular bases of cancer. This review provides recent advances in biosynthesized Au and Ag nanoparticles for seven of the most common and relevant cancers and their biological assessment. In addition, it provides a general idea of the in silico, in vitro, ex vivo, and in vivo models used for the anticancer evaluation of green biogenic metal-based nanoparticles.

Details

Title
Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications
Author
Tinajero-Díaz, Ernesto 1 ; Salado-Leza, Daniela 2   VIAFID ORCID Logo  ; Gonzalez, Carmen 3 ; Moisés Martínez Velázquez 4   VIAFID ORCID Logo  ; López, Zaira 5   VIAFID ORCID Logo  ; Bravo-Madrigal, Jorge 4 ; Knauth, Peter 5   VIAFID ORCID Logo  ; Flores-Hernández, Flor Y 4   VIAFID ORCID Logo  ; Herrera-Rodríguez, Sara Elisa 4 ; Navarro, Rosa E 6   VIAFID ORCID Logo  ; Cabrera-Wrooman, Alejandro 7 ; Krötzsch, Edgar 7   VIAFID ORCID Logo  ; García Carvajal, Zaira Y 4 ; Hernández-Gutiérrez, Rodolfo 4   VIAFID ORCID Logo 

 Departament d’Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028 Barcelona, Spain; [email protected]; Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Av. Normalistas 800, Col. Colinas de La Normal, Guadalajara 44270, Mexico; [email protected] (M.M.V.); [email protected] (J.B.-M.); [email protected] (F.Y.F.-H.); [email protected] (S.E.H.-R.) 
 Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava, Zona Universitaria, San Luis Potosí 78210, Mexico; [email protected] (D.S.-L.); [email protected] (C.G.); Cátedras CONACyT, México City 03940, Mexico 
 Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava, Zona Universitaria, San Luis Potosí 78210, Mexico; [email protected] (D.S.-L.); [email protected] (C.G.) 
 Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Av. Normalistas 800, Col. Colinas de La Normal, Guadalajara 44270, Mexico; [email protected] (M.M.V.); [email protected] (J.B.-M.); [email protected] (F.Y.F.-H.); [email protected] (S.E.H.-R.) 
 Centro Universitario de la Ciénega, Cell Biology Laboratory, Universidad de Guadalajara, Av. Universidad 1115, Ocotlán 47810, Mexico; [email protected] (Z.L.); [email protected] (P.K.) 
 Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City 04510, Mexico; [email protected] 
 Centro Nacional de Investigación y Atención de Quemados, Laboratory of Connective Tissue, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, México City 14389, Mexico; [email protected] (A.C.-W.); [email protected] (E.K.) 
First page
1719
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
19994923
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2584455481
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.