Abstract

Parkinson’s disease (PD) is a progressive chronic neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. Current PD therapeutic strategies are mainly symptomatic and can lead to motor complications overtime. As a result, alternative medicine may provide an effective adjuvant treatment for PD as an addition to or as a replacement of the conventional therapies. The aim of this work was to evaluate the effects of Bee Venom (BV) and dopamine (DA)-loaded nanoparticles in a reserpine-induced animal model of PD. After inducing PD with reserpine injection, different groups of male rats were treated with L-Dopa, BV, DA-nanoparticles. Our findings showed that BV and DA-nanoparticles administration restored monoamines, balanced glutamate/GABA levels, halted DNA fragmentation, decreased pro-inflammatory mediators (IL-1β and TNF-α), and elevated anti-inflammatory mediators (PON1) and neurotropic factor (BDNF) levels in comparison with conventional therapy of PD. Furthermore, in a reserpine-induced PD rat model, the ameliorative effects of BV were significantly superior to that of DA-nanoparticles. These findings imply that BV and DA-nanoparticles could be useful as adjuvant treatments for PD.

Details

Title
Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model
Author
Ahmed-Farid, Omar A 1 ; Taha, Mohamed 2   VIAFID ORCID Logo  ; Bakeer, Rofanda M 3 ; Radwan, Omyma K 1 ; Hendawy Hassan A M 4 ; Samaan Ayman 5 ; Yousef Einas 6 

1  National Organization for Drug Control and Research (NODCAR), Physiology Department, Giza, Egypt (GRID:grid.419698.b) 
2  Cairo University, Biochemistry Department, Faculty of Pharmacy, Giza, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286) 
3  Helwan University, Pathology Department, Faculty of Medicine, Helwan, Egypt (GRID:grid.412093.d) (ISNI:0000 0000 9853 2750) 
4  NODCAR, Analytical and Inorganic Chemistry Department, Giza, Egypt (GRID:grid.419698.b) 
5  Beni-Suef University, Medical Physiology Department, Faculty of Medicine, Beni-Suef, Egypt (GRID:grid.411662.6) (ISNI:0000 0004 0412 4932) 
6  Dar Al Uloom University, Basic Medical Sciences Department, College of Medicine, Riyadh, Kingdom of Saudi Arabia (GRID:grid.449023.8) (ISNI:0000 0004 1771 7446); Menoufia University, Histology and Cell Biology Department, Faculty of Medicine, Shibin El Kom, Egypt (GRID:grid.411775.1) (ISNI:0000 0004 0621 4712) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-021-00764-y
ProQuest document ID
2586673710
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.