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© 2021, Li et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.

Details

Title
Adiponectin preserves metabolic fitness during aging
Author
Li, Na; Zhao Shangang; Zhang Zhuzhen; Zhu, Yi; Gliniak, Christy M; Lavanya, Vishvanath; An, Yu A; May-yun, Wang; Deng Yingfeng; Zhu Qingzhang; Shan, Bo; Sherwood, Amber; Onodera Toshiharu; Oz, Orhan K; Gordillo, Ruth; Gupta, Rana K; Liu, Ming; Horvath, Tamas L; Dixit, Vishwa Deep; Scherer, Philipp E
University/institution
U.S. National Institutes of Health/National Library of Medicine
Publication year
2021
Publication date
2021
Publisher
eLife Sciences Publications Ltd.
e-ISSN
2050084X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2595190182
Copyright
© 2021, Li et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.