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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate the role of S1R in the development of neurological deficits after TBI. Adult male wild-type CD-1 (WT) and S1R knockout (S1R-/-) mice were subjected to lateral fluid percussion injury, and behavioral and histological outcomes were assessed for up to 12 months postinjury. Neurological deficits and motor coordination impairment were less pronounced in S1R-/- mice with TBI than in WT mice with TBI 24 h after injury. TBI-induced short-term memory impairments were present in WT but not S1R-/- mice 7 months after injury. Compared to WT animals, S1R-/- mice exhibited better motor coordination and less pronounced despair behavior for up to 12 months postinjury. TBI induced astrocyte activation in the cortex of WT but not S1R-/- mice. S1R-/- mice presented a significantly reduced GFAP expression in Bergmann glial cells in the molecular layer of the cerebellum compared to WT mice. Our findings suggest that S1R deficiency reduces TBI-induced motor coordination impairments by reducing GFAP expression in Bergmann glial cells in the cerebellum.

Details

Title
Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
Author
Stelfa, Gundega 1 ; Vavers, Edijs 2   VIAFID ORCID Logo  ; Svalbe, Baiba 2   VIAFID ORCID Logo  ; Serzants, Rinalds 3 ; Miteniece, Anna 4 ; Lauberte, Lasma 2 ; Grinberga, Solveiga 5 ; Gukalova, Baiba 5 ; Dambrova, Maija 3   VIAFID ORCID Logo  ; Zvejniece, Liga 2 

 Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia; [email protected] (E.V.); [email protected] (B.S.); [email protected] (R.S.); [email protected] (A.M.); [email protected] (L.L.); [email protected] (M.D.); [email protected] (L.Z.); Faculty of Veterinary Medicine, Latvia University of Life Sciences and Technologies, K Helmana Str. 8, LV-3001 Jelgava, Latvia 
 Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia; [email protected] (E.V.); [email protected] (B.S.); [email protected] (R.S.); [email protected] (A.M.); [email protected] (L.L.); [email protected] (M.D.); [email protected] (L.Z.) 
 Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia; [email protected] (E.V.); [email protected] (B.S.); [email protected] (R.S.); [email protected] (A.M.); [email protected] (L.L.); [email protected] (M.D.); [email protected] (L.Z.); Department of Pharmaceutical Chemistry, Riga Stradins University, Dzirciema Str. 16, LV-1007 Riga, Latvia 
 Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia; [email protected] (E.V.); [email protected] (B.S.); [email protected] (R.S.); [email protected] (A.M.); [email protected] (L.L.); [email protected] (M.D.); [email protected] (L.Z.); Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK 
 Laboratory of Physical Organic Chemistry, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia; [email protected] (S.G.); [email protected] (B.G.) 
First page
11611
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2596036862
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.