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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors.

Details

Title
A Review of Human Coronaviruses’ Receptors: The Host-Cell Targets for the Crown Bearing Viruses
Author
Nassar, Aaya 1   VIAFID ORCID Logo  ; Ibrahim, Ibrahim M 1 ; Amin, Fatma G 2 ; Merna Magdy 1 ; Elgharib, Ahmed M 1 ; Azzam, Eman B 3 ; Filopateer Nasser 4   VIAFID ORCID Logo  ; Kirllos Yousry 5 ; Shamkh, Israa M 6 ; Mahdy, Samah M 7 ; Elfiky, Abdo A 1 

 Biophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt; [email protected] (I.M.I.); [email protected] (F.G.A.); [email protected] (M.M.); [email protected] (A.M.E.) 
 Biophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt; [email protected] (I.M.I.); [email protected] (F.G.A.); [email protected] (M.M.); [email protected] (A.M.E.); Physics Department, Faculty of Science, Alexandria University, Alexandria 21519, Egypt 
 Physics Department, Medical Biophysics Division, Faculty of Science, Helwan University, Cairo 11511, Egypt; [email protected] 
 Biochemistry Department, Faculty of Science, Cairo University, Giza 12511, Egypt; [email protected] 
 Faculty of Medicine, Cairo University, Cairo 11511, Egypt; [email protected] 
 Independent Researcher, Giza 12511, Egypt; [email protected] 
 National Museum of Egyptian Civilization, Ain Elsira-Elfustat, Cairo 11511, Egypt; [email protected] 
First page
6455
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2596050588
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.