Abstract
Background
Initial reports have described the poor outcome of unexpected cardiac arrest (CA) in intensive care unit (ICU) among COVID-19 patients in China and the USA. However, there are scarce data on characteristics and outcomes of such CA patients in Europe.
Methods
Prospective registry in 35 French ICUs, including all in-ICU CA in COVID-19 adult patients with cardiopulmonary resuscitation (CPR) attempt. Favorable outcome was defined as modified Rankin scale ranging from 0 to 3 at day 90 after CA.
Results
Among the 2425 COVID-19 patients admitted to ICU from March to June 2020, 186 (8%) experienced in-ICU CA, of whom 146/186 (78%) received CPR. Among these 146 patients, 117 (80%) had sustained return of spontaneous circulation, 102 (70%) died in the ICU, including 48 dying within the first day after CA occurrence and 21 after withdrawal of life-sustaining therapy. Most of CA were non-shockable rhythm (90%). At CA occurrence, 132 patients (90%) were mechanically ventilated, 83 (57%) received vasopressors and 75 (51%) had almost three organ failures. Thirty patients (21%) had a favorable outcome. Sepsis-related organ failure assessment score > 9 before CA occurrence was the single parameter constantly associated with unfavorable outcome in multivariate analysis.
Conclusions
In-ICU CA incidence remains high among a large multicenter cohort of French critically ill adults with COVID-19. However, 21% of patients with CPR attempt remained alive at 3 months with good functional status. This contrasts with other recent reports showing poor outcome in such patients.
Trial registration: This study was retrospectively registered in ClinicalTrials.gov (NTC04373759) in April 2020 (https://www.clinicaltrials.gov/ct2/show/NCT04373759?term=acicovid&draw=2&rank=1).
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details

1 Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer, Hôpital Sainte Musse, Intensive Care Unit, Toulon, France (GRID:grid.489910.d)
2 Centre Hospitalier Victor Dupouy, Intensive Care Unit, Argenteuil, France (GRID:grid.414474.6) (ISNI:0000 0004 0639 3263)
3 Université de Paris, Intensive Care Unit, Centre Hospitalier Régional d’Orléans, Orléans. Inserm UMR1153, ECSTRRA, Paris, France (GRID:grid.508487.6) (ISNI:0000 0004 7885 7602)
4 Groupe Hospitalier Paris Saint Joseph, Intensive Care Unit, Paris, France (GRID:grid.414363.7) (ISNI:0000 0001 0274 7763)
5 Médecine Intensive Réanimation, CHU Lille, Inserm U1285, Université de Lille, CNRS, UMR 8576-UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France (GRID:grid.410463.4) (ISNI:0000 0004 0471 8845)
6 Hôpital de Bicêtre, Université Paris-Saclay, Assistance Publique Hôpitaux de Paris (AP-HP), Medical Intensive Care Unit, Le Kremlin-Bicêtre, France (GRID:grid.413784.d) (ISNI:0000 0001 2181 7253)
7 Groupe Hospitalier Sud Ile de France, Intensive Care Department, Melun, France (GRID:grid.413784.d)
8 DHU A-TVB, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Service d’anesthésie-réanimation chirurgicale, DMU CARE, Créteil, France (GRID:grid.412116.1) (ISNI:0000 0001 2292 1474)
9 Grand Hôpital de l’Est Francilien-site de Marne la Vallée, Intensive Care Unit, Jossigny, France (GRID:grid.412116.1)
10 Hôpital Nord Franche-Comté, Intensive Care Unit, Trévenans, France (GRID:grid.492689.8) (ISNI:0000 0004 0640 1948)
11 Pitié-Salpétrière hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Intensive Care Unit, Département R3S, Paris, France (GRID:grid.411439.a) (ISNI:0000 0001 2150 9058)
12 Centre Hospitalier de Versailles-site André Mignot, Intensive Care Unit, Le Chesnay, France (GRID:grid.418080.5) (ISNI:0000 0001 2177 7052)
13 Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer, Clinical Research Department, Toulon, France (GRID:grid.489910.d)
14 Assistance Publique Hôpitaux de Paris (AP-HP), Centre Hospitalier Universitaire Lariboisière, Medical and Toxicological Intensive Care Unit, Inserm U942, Paris, France (GRID:grid.50550.35) (ISNI:0000 0001 2175 4109)