Abstract

Table S2, Fig. Because of the significant relationship between diagnostic delay and early and late progression rate (see definition in Additional file 2: [...]the Chinese SOD1-mutant patients had a significantly lower age of onset and higher proportion of young-onset cases compared with the German counterparts, which may reflect a higher burden of genetic and environmental risk factors [9]. [...]the known prognostic factors BMI and age of onset for sporadic ALS were not associated with survival in the SOD1-carrying patients, indicating the different spectrum of disease-modifying factors.

Details

Title
A natural history comparison of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations
Author
Tang, Lu; Dorst, Johannes; Chen, Lu; Liu, Xiaolu; Ma, Yan; Günther, Kornelia; Michels, Sebastian; Müller, Kathrin; Freischmidt, Axel; Weishaupt, Jochen H; Fan, Dongsheng  VIAFID ORCID Logo  ; Ludolph, Albert C
Pages
1-3
Section
Letter
Publication year
2021
Publication date
2021
Publisher
BioMed Central
e-ISSN
20479158
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s40035-021-00266-x
ProQuest document ID
2599115269
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.