Abstract

Background and aim

The BRCA 1 and BRCA 2 genes are associated with an inherited susceptibility to breast cancer with a cumulative risk of 60% in BRCA 1 mutation carriers and of 30% in BRCA 2 mutation carriers. Several lifestyle factors could play a role in determining an individual’s risk of breast cancer. Obesity, changes in body size or unhealthy lifestyle habits such as smoking, alcohol consumption and physical inactivity have been evaluated as possible determinants of breast cancer risk. The aim of this study was to explore the current understanding of the role of harmful lifestyle and obesity or weight change in the development of breast cancer in female carriers of BRCA 1/2 mutations.

Methods

Articles were identified from MEDLINE in October 2020 utilizing related keywords; they were then read and notes, study participants, measures, data analysis and results were used to write this review.

Results

Studies with very large case series have been carried out but only few of them have shown consistent results. Additional research would be beneficial to better determine the actual role and impact of such factors.

Details

Title
Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review
Author
Daniele, A  VIAFID ORCID Logo  ; Divella, R; Pilato, B; Tommasi, S; Pasanisi, P; Patruno, M; Digennaro, M; Minoia, C; Dellino, M; Pisconti, S; Casamassima, P; Savino, E; Paradiso, A V
Pages
1-8
Section
Review
Publication year
2021
Publication date
2021
Publisher
BioMed Central
ISSN
17312302
e-ISSN
18974287
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13053-021-00199-6
ProQuest document ID
2599192156
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.