Full text

Turn on search term navigation

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Freezing of gait (FOG) is one of the most debilitating motor symptoms experienced by patients with Parkinson’s disease (PD), as it can lead to falls and a reduced quality of life. Evidence supports an association between FOG severity and cognitive functioning; however, results remain debatable. PD patients with (PDFOG+, n = 41) and without FOG (PDFOG–, n = 39) and control healthy subjects (n = 41) participated in this study. The NIH toolbox cognition battery, the Montreal Cognitive Assessment (MoCA), and the interval timing task were used to test cognitive domains. Measurements were compared between groups using multivariable models and adjusting for covariates. Correlation analyses, linear regression, and mediation models were applied to examine relationships among disease duration and severity, FOG severity, and cognitive functioning. Significant differences were observed between controls and PD patients for all cognitive domains. PDFOG+ and PDFOG– exhibited differences in Dimensional Change Card Sort (DCCS) test, interval timing task, and MoCA scores. After adjusting for covariates in two different models, PDFOG+ and PDFOG– differed in both MoCA and DCCS scores. In addition, significant relationships between FOG severity and cognitive function (MoCA, DCCS, and interval timing) were also found. Regression models suggest that FOG severity may be a predictor of cognitive impairment, and mediation models show the effects of cognitive impairment on the relationship between disease severity and FOG severity. Overall, this study provides insight into the relationship between cognitive and FOG severity in patients with PD, which could aid in the development of therapeutic interventions to manage both.

Details

Title
Relationships between Freezing of Gait Severity and Cognitive Deficits in Parkinson’s Disease
Author
Scholl, Jamie L 1 ; Espinoza, Arturo I 2 ; Rai, Wijdan 3 ; Leedom, Matt 4 ; Baugh, Lee A 1 ; Berg-Poppe, Patti 5 ; Singh, Arun 1   VIAFID ORCID Logo 

 Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA; [email protected] (J.L.S.); [email protected] (L.A.B.); Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD 57069, USA; [email protected] 
 Department of Neurology, University of Iowa, Iowa City, IA 52242, USA; [email protected] 
 Department of Neurosciences, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA; [email protected] 
 Avera Therapy, Sioux Falls, SD 57105, USA; [email protected] 
 Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD 57069, USA; [email protected]; Department of Physical Therapy, University of South Dakota, Vermillion, SD 57069, USA 
First page
1496
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20763425
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2602001098
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.