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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Accumulation of cervical and chin subcutaneous adipose tissues (SAT) represent known phenotypes of obesity. We aimed to evaluate the sensitivity of these fat storages to long-term weight-loss directed lifestyle-intervention and to assess their relations to bodily-adiposity, insulin-resistance, and cardiometabolic risk; We randomly assigned 278 participants with abdominal-obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets +/− physical-activity. All participants underwent an 18 month whole-body magnetic resonance imaging follow-up, from which we assessed cervical and chin SAT-areas; Participants (age = 48 years; 90% men; body-mass-index = 30.9 kg/m2) had an 18-month adherence-rate of 86%. Cervical-SAT and chin-SAT decreased after 6-months (−13.1% and −5.3%, respectively, p < 0.001). After 18-months only cervical-SAT remained decreased compared to baseline (−5%, p < 0.001). Cervical and chin-SAT 18-month changes were associated with changes in weight (r = 0.70, r = 0.66 respectively; <0.001 for both) and visceral-adipose-tissue (VAT; r = 0.35, r = 0.42 respectively; <0.001 for both). After adjustment to VAT, waist-circumference, or weight-changes, chin-SAT 18-month reduction was associated with favorable changes in fasting-glucose (β = 0.10; p = 0.05), HbA1c (β = 0.12; p = 0.03), and homeostasis-model-assessment-of-insulin-resistance (β = 0.12; p = 0.03). Cervical-SAT 18-month reduction was associated with decreased triglycerides (β = 0.16; p = 0.02) and leptin (β = 0.19; p = 0.01) independent of VAT; Cervical and chin-SATs are dynamic fat depots that correspond with weight-loss and are associated with changes in cardiometabolic profile. In long-term, chin-SAT displays a larger rebound compared with cervical-SAT. Chin-SAT accumulation is associated with in insulin-resistance, independent of central obesity. (ClinicalTrials identifier NCT01530724)

Details

Title
The Effect of Weight-Loss Interventions on Cervical and Chin Subcutaneous Fat Depots; the CENTRAL Randomized Controlled Trial
Author
Tsaban, Gal 1   VIAFID ORCID Logo  ; Bilitzky-Kopit, Avital 2 ; Meir, Anat Yaskolka 2   VIAFID ORCID Logo  ; Zelicha, Hila 2 ; Gepner, Yftach 3   VIAFID ORCID Logo  ; Shelef, Ilan 4   VIAFID ORCID Logo  ; Orr, Omri 2 ; Chassidim, Yoash 5 ; Sarusi, Benjamin 6 ; Ceglarek, Uta 7 ; Stumvoll, Michael 7 ; Blüher, Matthias 7   VIAFID ORCID Logo  ; Stampfer, Meir J 8 ; Shai, Iris 9   VIAFID ORCID Logo  ; Schwarzfuchs, Dan 10 

 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel; [email protected] (A.B.-K.); [email protected] (A.Y.M.); [email protected] (H.Z.); [email protected] (O.O.); [email protected] (I.S.); Department of Cardiology, Soroka University Medical Center, Beer-Sheva 84101, Israel 
 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel; [email protected] (A.B.-K.); [email protected] (A.Y.M.); [email protected] (H.Z.); [email protected] (O.O.); [email protected] (I.S.) 
 Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, School of Public Health, Tel-Aviv University, Tel-Aviv 96678, Israel; [email protected] 
 Division of Clinical Radiology, Soroka University Medical Center, Beer-Sheva 84101, Israel; [email protected] 
 Research Center, Soroka University Medical Center, Beer-Sheva 84101, Israel; [email protected] 
 Department of Medicine, Nuclear Research Center Negev, Dimona 84190, Israel; [email protected] (B.S.); [email protected] (D.S.) 
 Department of Medicine, University of Leipzig, 04103 Leipzig, Germany; [email protected] (U.C.); [email protected] (M.S.); [email protected] (M.B.) 
 Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; [email protected] 
 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel; [email protected] (A.B.-K.); [email protected] (A.Y.M.); [email protected] (H.Z.); [email protected] (O.O.); [email protected] (I.S.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; [email protected] 
10  Department of Medicine, Nuclear Research Center Negev, Dimona 84190, Israel; [email protected] (B.S.); [email protected] (D.S.); Emergency Medicine Division, Soroka University Medical Center, Beer-Sheva 84101, Israel 
First page
3827
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20726643
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2602147064
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.