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Abstract
The purpose of current study was to evaluate different optical coherence tomography angiography (OCTA) metrics in eyes with diabetic retinopathy with and without diabetic macular edema (DME). In this retrospective study, macular OCTA images of eyes with non-proliferative or proliferative diabetic retinopathy were evaluated. Vascular density, vascular complexity and non-perfusion densities were compared between eyes with and without DME. One-hundred-thirty-eight eyes of 92 diabetic patients including 49 eyes with DME were included. In multivariate analysis, the presence of DME was positively associated with geometric perfusion deficit (GPD) in superficial capillary plexus (SCP), capillary non-perfusion (CNP) of SCP, and GPD in deep capillary plexus (DCP) (all P < 0.05). In eyes with DME, central foveal thickness was associated with VD ratio (SCP/DCP) (P = 0.001) and FAZ area (P = 0.001). In conclusion, in eyes with diabetic retinopathy, the presence of DME was associated with more extensive capillary non-perfusion compared to those with no macular edema.
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Details
1 Iran University of Medical Sciences, Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Tehran, Iran (GRID:grid.411746.1) (ISNI:0000 0004 4911 7066)
2 Tehran University of Medical Sciences, Eye Research Center, Farabi Eye Hospital, Tehran, Iran (GRID:grid.411705.6) (ISNI:0000 0001 0166 0922)
3 Islamic Azad University, Young Researchers and Elite club, Tehran Medical Sciences, Tehran, Iran (GRID:grid.411463.5) (ISNI:0000 0001 0706 2472)
4 Iran University of Medical Sciences, Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Tehran, Iran (GRID:grid.411746.1) (ISNI:0000 0004 4911 7066); Iran University of Medical Sciences, Stem Cell and Regenerative Medicine Research Center, Tehran, Iran (GRID:grid.411746.1) (ISNI:0000 0004 4911 7066)