Abstract

Development of distant metastasis is the main cause of deaths in prostate cancer (PCa) patients. Understanding the mechanism of PCa metastasis is of utmost importance to improve its prognosis. The role of exosomal long noncoding RNA (lncRNA) has been reported not yet fully understood in the metastasis of PCa. Here, we discovered an exosomal lncRNA HOXD-AS1 is upregulated in castration resistant prostate cancer (CRPC) cell line derived exosomes and serum exosomes from metastatic PCa patients, which correlated with its tissue expression. Further investigation confirmed exosomal HOXD-AS1 promotes prostate cancer cell metastasis in vitro and in vivo by inducing metastasis associated phenotype. Mechanistically exosomal HOXD-AS1 was internalized directly by PCa cells, acting as competing endogenous RNA (ceRNA) to modulate the miR-361-5p/FOXM1 axis, therefore promoting PCa metastasis. In addition, we found that serum exosomal HOXD-AS1 was upregulated in metastatic PCa patients, especially those with high volume disease. And it is correlated closely with Gleason Score, distant and nodal metastasis, Prostatic specific antigen (PSA) recurrence free survival, and progression free survival (PFS). This sheds a new insight into the regulation of PCa distant metastasis by exosomal HOXD-AS1 mediated miR-361-5p/FOXM1 axis, and provided a promising liquid biopsy biomarker to guide the detection and treatment of metastatic PCa.

Details

Title
Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
Author
Jiang Yongming 1 ; Zhao, Hui 2   VIAFID ORCID Logo  ; Chen, Yuxiao 2 ; Li Kangjian 3 ; Li Tianjie 4 ; Chen, Jianheng 2 ; Zhang, Baiyu 2 ; Guo Caifen 4 ; Liangliang, Qing 4 ; Shen Jihong 2 ; Liu, Xiaodong 2   VIAFID ORCID Logo  ; Gu, Peng 2   VIAFID ORCID Logo 

 The 1st Affiliated Hospital of Kunming Medical University, Department of Urology, Kunming, China (GRID:grid.285847.4) (ISNI:0000 0000 9588 0960); The 2nd Affiliated Hospital of Kunming Medical University, Department of Urology, Kunming, China (GRID:grid.415444.4) (ISNI:0000 0004 1800 0367) 
 The 1st Affiliated Hospital of Kunming Medical University, Department of Urology, Kunming, China (GRID:grid.285847.4) (ISNI:0000 0000 9588 0960); Yunnan Province Clinical Research Center for Chronic Kidney Disease, Kunming, China (GRID:grid.285847.4) 
 The Second People’s Hospital of Qujing City, Department of Urology, Qujing City, China (GRID:grid.285847.4) 
 The 1st Affiliated Hospital of Kunming Medical University, Department of Urology, Kunming, China (GRID:grid.285847.4) (ISNI:0000 0000 9588 0960) 
Publication year
2021
Publication date
Dec 2021
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2606281773
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.