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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The objective of the present study was to review the existing data on the association between Zn status and characteristics of gut microbiota in various organisms and the potential role of Zn-induced microbiota in modulating systemic effects. The existing data demonstrate a tight relationship between Zn metabolism and gut microbiota as demonstrated in Zn deficiency, supplementation, and toxicity studies. Generally, Zn was found to be a significant factor for gut bacteria biodiversity. The effects of physiological and nutritional Zn doses also result in improved gut wall integrity, thus contributing to reduced translocation of bacteria and gut microbiome metabolites into the systemic circulation. In contrast, Zn overexposure induced substantial alterations in gut microbiota. In parallel with intestinal effects, systemic effects of Zn-induced gut microbiota modulation may include systemic inflammation and acute pancreatitis, autism spectrum disorder and attention deficit hyperactivity disorder, as well as fetal alcohol syndrome and obesity. In view of both Zn and gut microbiota, as well as their interaction in the regulation of the physiological functions of the host organism, addressing these targets through the use of Zn-enriched probiotics may be considered an effective strategy for health management.

Details

Title
Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
Author
Skalny, Anatoly V 1 ; Aschner, Michael 2   VIAFID ORCID Logo  ; Xin Gen Lei 3   VIAFID ORCID Logo  ; Gritsenko, Viktor A 4 ; Santamaria, Abel 5 ; Alekseenko, Svetlana I 6 ; Nagaraja, Tejo Prakash 7   VIAFID ORCID Logo  ; Jung-Su, Chang 8   VIAFID ORCID Logo  ; Sizova, Elena A 9 ; Chao, Jane C J 10   VIAFID ORCID Logo  ; Aaseth, Jan 11   VIAFID ORCID Logo  ; Tinkov, Alexey A 12 

 Laboratory of Molecular Dietetics, World-Class Research Center, Digital Biodesign and Personalized Healthcare, IM Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia; [email protected] (A.V.S.); [email protected] (M.A.); [email protected] (J.A.); Department of Bioelementology, K.G. Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia 
 Laboratory of Molecular Dietetics, World-Class Research Center, Digital Biodesign and Personalized Healthcare, IM Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia; [email protected] (A.V.S.); [email protected] (M.A.); [email protected] (J.A.); Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA 
 Department of Animal Science, Cornell University, Ithaca, NY 14853, USA; [email protected] 
 Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, 460000 Orenburg, Russia; [email protected] 
 Laboratorio de Aminoácidos Excitadores/Laboratorio de Neurofarmacología Molecular y Nanotecnología, Instituto Nacional de Neurología y Neurocirugía, Mexico City 14269, Mexico; [email protected] 
 Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, 190013 St. Petersburg, Russia; [email protected]; Department of Otorhinolaryngology, I.I. Mechnikov North-Western State Medical University, 195067 St. Petersburg, Russia; K.A. Raukhfus Children’s City Multidisciplinary Clinical Center for High Medical Technologies, 191036 St. Petersburg, Russia 
 School of Energy and Environment, Thapar Institute Engineering and Technology, Patiala 147004, Punjab, India; [email protected] 
 School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan; [email protected] (J.-S.C.); [email protected] (J.C.J.C.); Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan 
 Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, 460000 Orenburg, Russia; [email protected] 
10  School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan; [email protected] (J.-S.C.); [email protected] (J.C.J.C.); Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan 
11  Laboratory of Molecular Dietetics, World-Class Research Center, Digital Biodesign and Personalized Healthcare, IM Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia; [email protected] (A.V.S.); [email protected] (M.A.); [email protected] (J.A.); Research Department, Innlandet Hospital Trust, 2380 Brumunddal, Norway 
12  Laboratory of Molecular Dietetics, World-Class Research Center, Digital Biodesign and Personalized Healthcare, IM Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia; [email protected] (A.V.S.); [email protected] (M.A.); [email protected] (J.A.); Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Sovetskaya Str. 14, 150000 Yaroslavl, Russia 
First page
13074
Publication year
2021
Publication date
2021
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2608115518
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.