Abstract

In the present study, nickel nanoparticles were green-synthesized using the aqueous extract of Fumaria officinalis. The synthesized NiNPs@F. officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The antioxidant and anti-ovarian cancer activity of NiNPs@F. officinalis was evaluated. The nanoparticles were formed in a spherical shape in the range of 16.85 to 49.04 nm for the particle size. In the antioxidant test, the IC50 of F. officinalis, NiNPs@F. officinalis, and BHT against DPPH free radicals were 253, 145, and 107 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with NiNPs@F. officinalis were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. PA-1, Caov-3, SW-626, and SK-OV-3. The viability of malignant ovarian cell line reduced dose-dependently in the presence of NiNPs@F. officinalis. The IC50 of NiNPs@F. officinalis were 375, 225, 246, and 279 µg/mL against PA-1, Caov-3, SW-626, and SK-OV-3 cell lines, respectively. After the clinical study, nickel nanoparticles containing F. officinalis leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human ovarian cancer.

Details

Title
Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer
Author
Huang, Yan 1 ; Zhu, Chunxia 2 ; Xie, Rongkai 1 ; Ni, Ming 3 

 Department of Obstetrics and Gynecology, Chongqing Xinqiao Hospital, Second Affiliated Hospital of Army Medical University, Chongqing, China 
 Dapartment of Gynecology, Xianning Central Hospital (The first Affiliated Hospital of Hubei University of Science and Technology), Xianning, Hubei, China 
 Department of Obstetrics and Gynecology, Wuhan Hanyang hospital, Wuhan, China 
Pages
368-381
Publication year
2021
Publication date
Dec 2021
Publisher
Taylor & Francis Ltd.
ISSN
17458080
e-ISSN
17458099
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2611009297
Copyright
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.