Abstract

Background

There are limited data on the clinical benefits of adding surgical resection in patients with recurrent or metastatic gastrointestinal stromal tumors (GISTs). This protocol outlines the planned scope and methods for a systematic review and meta-analysis update that will compare the clinical outcomes of surgical resection combined with tyrosine kinase inhibitor (TKI) with TKI treatment alone in patients with recurrent or metastatic GISTs.

Methods

This review will update a previously published systematic review by our team. This protocol is presented in accordance with the PRISMA-P guideline. PubMed, Embase, and Cochrane Central Register of Controlled Trials will be systematically searched and supplemented by a secondary screening of the references of all included studies. We will include randomized controlled trials (RCTs) and non-randomized studies (NRS) in this review update. The outcomes evaluated will be overall survival and progression-free survival. Two reviewers will independently screen and select studies, extract data from the included studies, and assess the risk of bias of the included studies. Data extracted from RCTs and NRS will be analysed and reported separately. Preplanned subgroup analyses and sensitivity analyses are detailed within this protocol. The strength of the body of evidence will be assessed using GRADE.

Discussion

This systematic review and meta-analysis update will provide a current assessment of the evidence for the role of surgery in patients with recurrent or metastatic advanced GISTs. These findings will be used by the Chinese Society of Clinical Oncology (CSCO) GIST guideline recommendations on surgical treatment for recurrent or metastatic advanced GIST patients in China.

Systematic review registration

This protocol was prospectively registered in the Open Science Framework Registry (https://osf.io/xus7m).

Details

Title
Surgical resection for patients with recurrent or metastatic gastrointestinal stromal tumors: a protocol for a systematic review and meta-analysis update
Author
Cai, Zhaolun; Xin, Chunyu; Jiang, Zhiyuan; Liu, Chunyu; Shen, Chaoyong; Zhao, Guozhen; Yin, Yuan; Yin, Xiaonan; Zhou, Zhao; Mingchun Mu; Zhang, Bo  VIAFID ORCID Logo 
Pages
1-5
Section
Protocol
Publication year
2021
Publication date
2021
Publisher
BioMed Central
e-ISSN
20464053
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13643-021-01863-7
ProQuest document ID
2611290068
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.