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Copyright © 2021 Weirong Zhu et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Fibroblasts are the essential cell type of skin, highly involved in the wound regeneration process. In this study, we sought to screen out the novel genes which act important roles in diabetic fibroblasts through bioinformatic methods. A total of 811 and 490 differentially expressed genes (DEGs) between diabetic and normal fibroblasts were screened out in GSE49566 and GSE78891, respectively. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from miRWalk. Consequently, the integrated bioinformatic analyses revealed the shared KEGG pathways between DEG-identified and diabetes-related pathways were functionally enriched in the MAPK signaling pathway, and the MAPKAPK3, HSPA2, TGFBR1, and p53 signaling pathways were involved. Finally, ETV4 and NPE2 were identified as the targeted transcript factors of MAPKAPK3, HSPA2, and TGFBR1. Our findings may throw novel sight in elucidating the molecular mechanisms of fibroblast pathologies in patients with diabetic wounds and targeting new factors to advance diabetic wound treatment in clinic.

Details

Title
Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound
Author
Zhu, Weirong 1 ; Fang, Qin 2 ; Liu, Zhao 1 ; Chen, Qiming 1   VIAFID ORCID Logo 

 Department of Hand and Foot Surgery, Huizhou Municipal Central Hospital, Huizhou 516001, China 
 Department of Breast Surgery, Huizhou Municipal Central Hospital, Huizhou 516001, China 
Editor
Yun-Feng Yang
Publication year
2021
Publication date
2021
Publisher
John Wiley & Sons, Inc.
ISSN
23146745
e-ISSN
23146753
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2611360186
Copyright
Copyright © 2021 Weirong Zhu et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.