It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
All parts of Thanakha (Hesperethusa crenulata R.) have been used as traditional skin care herbal material in Myanmar. In this study, coumarins from H. crenulata R. bark were isolated through solvent extraction, systematic solvent fractionation, and repeated column chromatography. Spectroscopic analyses using ESI–MS, 1D NMR (1H and 13C), 2D NMR (gHSQC and gHMBC), specific rotation, circular dichroism, and IR spectrometry revealed three coumarins 2R-7-hydroxy-8-(2,3-dihydroxy-3-methylbutyl)-coumarin (compound 1), peucedanol (compound 2), and methylpeucedanol (compound 3), which were first isolated from Thanakha tree. Antioxidant capacities of three coumarins decreased as follows: compound 2 > compound 3 > compound 1. Treatments of lipopolysaccharide-induced THP-1 human monocytic cells with compounds 2 and 3 at 378.8 μM and 359.7 μM inhibited tumor necrosis factor-α production by approximately 32.7% and 13.3%, respectively, compared with the negative control. In summary, these results suggest that Thanakha bark extracts can be used as a potent antioxidant and anti-inflammatory source for cosmetic ingredients.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Kyung Hee University, Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Yongin, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)
2 Kyung Hee University, Department of Food Science and Biotechnology, Yongin, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)
3 Kyung Hee University, Skin Biotechnology Center, Suwon, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)
4 Jangan University, Department of Food and Nutrition, Hwaseong, Republic of Korea (GRID:grid.495942.7) (ISNI:0000 0004 6018 4876)
5 Cytus H&B, Cheongju, Republic of Korea (GRID:grid.495942.7)
6 Kyung Hee University, Department of Food Science and Biotechnology, Yongin, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818); Kyung Hee University, Skin Biotechnology Center, Suwon, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)