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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Poly(ethylene glycol) diglycidyl ether (PEGDE) is widely used to cross-link polymers, particularly in the pharmaceutical and biomaterial sectors. However, the subcutaneous toxicity of PEGDE has not yet been assessed. PEGDE samples (500–40,000 μg/mouse) were subcutaneously injected into the paraspinal dorsum of BALB/c male mice. Cage-side observations were carried out with measurement of organ weight, body weight variation, and feed intake, as well as histopathological characterization on day 28 post-exposure. Mice that received 40,000 μg of PEGDE showed severe toxic response and had to be euthanized. Subcutaneous injection of PEGDE did not alter feed intake and organ weight; however, the body weight variation of mice injected with 20,000 μg of PEGDE was significantly lower than that of the other groups. Exposure to 10,000 and 20,000 μg of PEGDE induced epidermal ulcer formation and hair loss. The histology of skin tissue in mice administered with 20,000 μg of PEGDE showed re-epithelialized or unhealed wounds. However, the liver, spleen, and kidneys were histologically normal. Collectively, PEGDE, particularly above 10,000 μg/mouse, caused subcutaneous toxicity with ulceration, but no toxicity in the other organs. These results may indicate the optimal concentration of subcutaneously injected PEGDE.

Details

Title
Toxicity Assessment of a Single Dose of Poly(ethylene glycol) Diglycidyl Ether (PEGDE) Administered Subcutaneously in Mice
Author
Do-Hyun, Kim 1 ; Jong-Hyeon Han 1   VIAFID ORCID Logo  ; Kwon, Hyuk-Cheol 1   VIAFID ORCID Logo  ; Su-Jin, Lim 1 ; Seo-Gu, Han 1 ; Hyun-Su, Jung 1 ; Keyong-Ho, Lee 2 ; Ju-Hee Kang 2 ; Sung-Gu, Han 1   VIAFID ORCID Logo 

 Toxicology Laboratory, Sanghuh College of Life Science, Konkuk University, 120 Neungdong-ro, Seoul 05029, Korea; [email protected] (D.-H.K.); [email protected] (J.-H.H.); [email protected] (H.-C.K.); [email protected] (S.-J.L.); [email protected] (S.-G.H.); [email protected] (H.-S.J.) 
 R&D Department, Across Co., Ltd., Chuncheon 24398, Korea; [email protected] (K.-H.L.); [email protected] (J.-H.K.) 
First page
354
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
23056304
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2612845178
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.