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Abstract
Zika virus (ZIKV) is a mosquito-borne virus that has a high risk of inducing Guillain–Barré syndrome and microcephaly in newborns. Because vaccination is considered the most effective strategy against ZIKV infection, we designed a recombinant vaccine utilizing the baculovirus expression system with two strains of ZIKV envelope protein (MR766, Env_M; ZBRX6, Env_Z). Animals inoculated with Env_M and Env_Z produced ZIKV-specific antibodies and secreted effector cytokines such as interferon-γ, tumor necrosis factor-α, and interleukin-12. Moreover, the progeny of immunized females had detectable maternal antibodies that protected them against two ZIKV strains (MR766 and PRVABC59) and a Dengue virus strain. We propose that the baculovirus expression system ZIKV envelope protein recombinant provides a safe and effective vaccine strategy.
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Details
1 Kangwon National University, College of Veterinary Medicine and Institute of Veterinary Science, Chuncheon, Republic of Korea (GRID:grid.412010.6) (ISNI:0000 0001 0707 9039)
2 Kangwon National University, College of Biological Sciences, Chuncheon, Republic of Korea (GRID:grid.412010.6) (ISNI:0000 0001 0707 9039)