Abstract

Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes.

Ambient temperature significantly affects embryogenesis, but adaptive molecular mechanisms that respond to temperature remain unclear. Here, the authors identified species-specific thermal sensitivity of Notch signaling in developing amniote brains.

Details

Title
Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains
Author
Nomura Tadashi 1   VIAFID ORCID Logo  ; Nagao Kohjiro 2 ; Shirai Ryo 3 ; Gotoh Hitoshi 1 ; Umeda Masato 4   VIAFID ORCID Logo  ; Ono Katsuhiko 1 

 Kyoto Prefectural University of Medicine, INAMORI Memorial Building, Developmental Neurobiology, Sakyo-ku, Japan (GRID:grid.272458.e) (ISNI:0000 0001 0667 4960) 
 Kyoto University, Katsura, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Nishikyo-ku, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033); Kyoto Pharmaceutical University, Department of Biophysical Chemistry, Yamashina-ku, Japan (GRID:grid.411212.5) (ISNI:0000 0000 9446 3559) 
 Niigata University, School of Medicine, Niigata City, Japan (GRID:grid.260975.f) (ISNI:0000 0001 0671 5144); Japanese Red Cross Society Kyoto Daini Hospital, Kamigyo-ku, Japan (GRID:grid.415627.3) (ISNI:0000 0004 0595 5607) 
 Kyoto University, Katsura, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Nishikyo-ku, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033); HOLO BIO Co., Nichikyo-ku, Japan (GRID:grid.258799.8) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2619578641
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.