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Abstract
Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes.
Ambient temperature significantly affects embryogenesis, but adaptive molecular mechanisms that respond to temperature remain unclear. Here, the authors identified species-specific thermal sensitivity of Notch signaling in developing amniote brains.
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1 Kyoto Prefectural University of Medicine, INAMORI Memorial Building, Developmental Neurobiology, Sakyo-ku, Japan (GRID:grid.272458.e) (ISNI:0000 0001 0667 4960)
2 Kyoto University, Katsura, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Nishikyo-ku, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033); Kyoto Pharmaceutical University, Department of Biophysical Chemistry, Yamashina-ku, Japan (GRID:grid.411212.5) (ISNI:0000 0000 9446 3559)
3 Niigata University, School of Medicine, Niigata City, Japan (GRID:grid.260975.f) (ISNI:0000 0001 0671 5144); Japanese Red Cross Society Kyoto Daini Hospital, Kamigyo-ku, Japan (GRID:grid.415627.3) (ISNI:0000 0004 0595 5607)
4 Kyoto University, Katsura, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Nishikyo-ku, Japan (GRID:grid.258799.8) (ISNI:0000 0004 0372 2033); HOLO BIO Co., Nichikyo-ku, Japan (GRID:grid.258799.8)