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Copyright © 2021 Burak Cem Soner et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and the main cause of PD is still not known. Until now, no cure for Parkinson’s disease is yet in sight. Caffeic acid phenethyl ester (CAPE) is a polyphenolic component of the propolis, which can be derived from honeybee hive propolis. We aimed to determine the effect of intrastriatal CAPE administration as a neuroprotective agent on 6-hydroxydopamine (6-OHDA)-induced PD model. Adult male Wistar rats weighing 280–320 g were used. The PD model was induced with unilateral intrastriatal 6-OHDA injection. Treatment groups received 20 μmol/5 μL/4 day and 80 μmol/5 μL/4 day CAPE 24 h after 6-OHDA injection. Eight days after 6-OHDA application, behavioral studies (adhesive tape removal test, open-field test, cylinder test, and apomorphine-induced asymmetric rotational behavior) were performed once more to compare the effects of CAPE on behavior tests. Striatal histological verifications, immunohistochemistry, and stereological quantitation were performed. Our results for the first time showed that, besides improving the motor performance, CAPE treatment also prevents 6-OHDA-induced loss of TH-positive neurons. From our results, CAPE may be a promising clinical agent in the treatment of PD.

Details

Title
Neuroprotective Effect of Intrastriatal Caffeic Acid Phenethyl Ester Treatment in 6-OH Dopamine Model of Parkinson’s Disease in Rats
Author
Soner, Burak Cem 1   VIAFID ORCID Logo  ; Acikgoz, Eda 2   VIAFID ORCID Logo  ; Salim Yalcin Inan 3   VIAFID ORCID Logo  ; Sule Ayla 4   VIAFID ORCID Logo  ; Sahin, Ayse Saide 3   VIAFID ORCID Logo  ; Oktem, Gulperi 5   VIAFID ORCID Logo 

 Izmir Democracy University, Faculty of Medicine, Department of Pharmacology, 35100 Izmir, Turkey 
 Van Yuzuncu Yil University, Faculty of Medicine, Department of Histology and Embryology, 65080 Van, Turkey 
 Necmettin Erbakan University, Meram Faculty of Medicine, Department of Medical Pharmacology, 42100 Konya, Turkey 
 Istanbul Medipol University, School of Medicine, Department of Histology and Embryology, İstanbul, Turkey 
 Ege University, Faculty of Medicine, Department of Histology and Embryology, 35100 Izmir, Turkey 
Editor
Cristine Alves da Costa
Publication year
2021
Publication date
2021
Publisher
John Wiley & Sons, Inc.
ISSN
20908083
e-ISSN
20420080
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2620747511
Copyright
Copyright © 2021 Burak Cem Soner et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/