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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Mentha spicata is one of the most popular species in the genus, and it is of great interest as a gastrointestinal and sedative agent in the folk medicine system. In this study, different M. spicata extracts, obtained by the use of four solvents (hexane, chloroform, acetone and acetone/water) were chemically characterized using HPLC-ESI-MS n, which allowed for identification of 27 phenolic compounds. The extracts’ antioxidant and enzyme inhibitory properties were investigated. In addition, neuroprotective effects were evaluated in hypothalamic HypoE22 cells, and the ability of the extracts to prevent the hydrogen peroxide-induced degradation of dopamine and serotonin was observed. The best antioxidant effect was achieved for all the extraction methods using acetone/water as a solvent. These extracts were the richest in acacetin, eriodictyol, hesperidin, sagerinic acid, naringenin, luteolin, chlorogenic acid, chrysoeriol and apigenin. The intrinsic antioxidant and enzyme inhibition properties of the acetone/water extract could also explain, albeit partially, its efficacy in preventing prostaglandin E2 overproduction and dopamine depletion (82.9% turnover reduction) in HypoE22 cells exposed to hydrogen peroxide. Thus, our observations can provide a scientific confirmation of the neuromodulatory and neuroprotective effects of M. spicata.

Details

Title
Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle
Author
Zengin, Gokhan 1   VIAFID ORCID Logo  ; Ak, Gunes 1 ; Ceylan, Ramazan 1 ; Uysal, Sengul 2   VIAFID ORCID Logo  ; Llorent-Martínez, Eulogio 3   VIAFID ORCID Logo  ; Di Simone, Simonetta Cristina 4 ; Rapino, Monica 5 ; Acquaviva, Alessandra 4   VIAFID ORCID Logo  ; Libero, Maria Loreta 4   VIAFID ORCID Logo  ; Chiavaroli, Annalisa 4 ; Recinella, Lucia 4 ; Leone, Sheila 4 ; Brunetti, Luigi 4 ; Cataldi, Amelia 4 ; Giustino Orlando 4 ; Menghini, Luigi 4   VIAFID ORCID Logo  ; Ferrante, Claudio 4   VIAFID ORCID Logo  ; Balaha, Marwa 6   VIAFID ORCID Logo  ; Viviana di Giacomo 4   VIAFID ORCID Logo 

 Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey; [email protected] (G.Z.); [email protected] (G.A.); [email protected] (R.C.) 
 Halil Bayraktar Health Services Vocational College, Erciyes University, 38280 Kayseri, Turkey; [email protected]; Drug Application and Research Center, Erciyes University, 38280 Kayseri, Turkey 
 Department of Physical and Analytical Chemistry, Campus Las Lagunillas, University of Jaén, E-23071 Jaen, Spain; [email protected] 
 Botanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy; [email protected] (S.C.D.S.); [email protected] (A.A.); [email protected] (M.L.L.); [email protected] (A.C.); [email protected] (L.R.); [email protected] (S.L.); [email protected] (L.B.); [email protected] (A.C.); [email protected] (G.O.); [email protected] (L.M.); [email protected] (M.B.); [email protected] (V.d.G.) 
 Genetic Molecular Institute of CNR, Unit of Chieti, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy; [email protected] 
 Botanic Garden “Giardino dei Semplici”, Department of Pharmacy, “Gabriele d’Annunzio” University, Via dei Vestini 31, 66100 Chieti, Italy; [email protected] (S.C.D.S.); [email protected] (A.A.); [email protected] (M.L.L.); [email protected] (A.C.); [email protected] (L.R.); [email protected] (S.L.); [email protected] (L.B.); [email protected] (A.C.); [email protected] (G.O.); [email protected] (L.M.); [email protected] (M.B.); [email protected] (V.d.G.); Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El Sheikh 33516, Egypt 
First page
233
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
22237747
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2621366107
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.