Abstract

Hyperlipidemia characterized by abnormal deposition of cholesterol in arteries can cause atherosclerosis and coronary artery occlusion, leading to atherosclerotic coronary heart disease. The body prevents atherosclerosis by reverse cholesterol transport to mobilize and excrete cholesterol and other lipids. Apolipoprotein A1, the major component of high-density lipoprotein, plays a key role in reverse cholesterol transport. Here, we reviewed the role of apolipoprotein A1-targeting molecules in antiatherosclerosis therapy, in particular ATP-binding cassette transporter A1, lecithin-cholesterol acyltransferase, and scavenger receptor class B type 1.

Details

Title
Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives
Author
Xu, Xiuting  VIAFID ORCID Logo  ; Song, Zikai; Mao, Bao  VIAFID ORCID Logo  ; Xu, Guoliang  VIAFID ORCID Logo 
Editor
Victor Garcia
Publication year
2022
Publication date
2022
Publisher
John Wiley & Sons, Inc.
ISSN
17555914
e-ISSN
17555922
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1155/2022/4610834
ProQuest document ID
2622086890
Copyright
Copyright © 2022 Xiuting Xu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/