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Abstract
We examined the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) were analyzed in this prospective study. We divided the study period into four 6-yearly quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV + hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). The incident cases of HCC per quarter of the study period were 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), and 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients < 60 years, 60–69 years, 70–79 years, and ≥ 80 years were 3711 (18.1%), 6652 (32.4%), 7448 (36.2%), and 2736 (13.3%), respectively. The average age of newly-diagnosed patients increased in each quarter. HCC was associated with HBV, HBV + HCV, and HCV infections and non-BC in 2997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased. HCC incident cases tend to increase in the elderly and in non-BC patients; in contrast, HCC incident cases due to HCV tend to decrease.
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1 Kurume University School of Medicine, Division of Gastroenterology, Department of Medicine, Kurume, Japan (GRID:grid.410781.b) (ISNI:0000 0001 0706 0776)
2 Nagasaki University Graduate School of Biomedical Sciences, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Department of Hepatology, Omura, Japan (GRID:grid.174567.6) (ISNI:0000 0000 8902 2273)
3 National Hospital Organization Kyushu Medical Center, Department of Hepato-Biliary-Pancreatic Surgery, Fukuoka, Japan (GRID:grid.415613.4)
4 Kumamoto University, Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto, Japan (GRID:grid.274841.c) (ISNI:0000 0001 0660 6749)
5 Oita University, Department of Gastroenterology, Faculty of Medicine, Yufu, Japan (GRID:grid.412334.3) (ISNI:0000 0001 0665 3553)
6 Nanpuh Hospital, Department of Hepatology, Kagoshima, Japan (GRID:grid.412334.3)
7 University of Occupational and Environmental Health, Third Department of Internal Medicine, School of Medicine, Kitakyushu, Japan (GRID:grid.271052.3) (ISNI:0000 0004 0374 5913)
8 Fukuoka University, Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka, Japan (GRID:grid.411497.e) (ISNI:0000 0001 0672 2176)
9 University of Miyazaki, Division of Gastroenterology and Hematology, Department of Internal Medicine, Faculty of Medicine, Miyazaki, Japan (GRID:grid.410849.0) (ISNI:0000 0001 0657 3887)
10 Kyushu University, Department of Surgery and Science, Graduate School of Medical Sciences, Fukuoka, Japan (GRID:grid.177174.3) (ISNI:0000 0001 2242 4849)
11 Japanese Red Cross Fukuoka Hospital, Department of Hepatology, Fukuoka, Japan (GRID:grid.415148.d) (ISNI:0000 0004 1772 3723)
12 Saga University Hospital, Liver Center, Saga, Japan (GRID:grid.416518.f)
13 Nagasaki University Hospital, Department of Gastroenterology and Hepatology, Nagasaki, Japan (GRID:grid.411873.8) (ISNI:0000 0004 0616 1585)
14 National Hospital Organization Oita Medical Center, Department of Gastroenterology, Oita, Japan (GRID:grid.415661.1) (ISNI:0000 0004 0642 4955)
15 Kagoshima University Graduate School of Medical and Dental Sciences, Digestive and Lifestyle Diseases, Kagoshima, Japan (GRID:grid.258333.c) (ISNI:0000 0001 1167 1801)
16 National Hospital Organization Kyushu Medical Center, Department of Gastroenterology, Fukuoka, Japan (GRID:grid.415613.4)
17 Fukuoka Tokushukai Hospital, Department of Gastroenterology, Kasuga, Japan (GRID:grid.415151.5) (ISNI:0000 0004 0569 0055)
18 University of the Ryukyus Hospital, First Department of Internal Medicine, Nakagami, Japan (GRID:grid.267625.2) (ISNI:0000 0001 0685 5104)
19 Nagasaki Rosai Hospital, Department of Gastroenterology, Sasebo, Japan (GRID:grid.416399.0) (ISNI:0000 0004 1774 9106)